UniProt Accession

 HSF4_HUMAN; Q9ULV5; Q99472; Q9ULV6 

Genbank Protein ID

 D87673; AB029347; AB029348; AC074143 

Genbank Nucleotide ID

 BAA13433.1; BAA84581.1; BAA84582.1 

Protein Name

 Heat shock factor protein 4 

Protein Synonyms/Alias

 HSF 4; hHSF4; Heat shock transcription factor 4; HSTF 4 

Gene Name

 HSF4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
287	SSDGRREKGLALLKE	sumoylation	[1]

Reference

 [1] A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.
 Galisson F, Mahrouche L, Courcelles M, Bonneil E, Meloche S, Chelbi-Alix MK, Thibault P.
 Mol Cell Proteomics. 2011 Feb;10(2):M110.004796. [PMID: 21098080] 

Functional Description

 DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. 

Sequence Annotation

 DNA_BIND 17 121 By similarity.
 REGION 129 203 Hydrophobic repeat HR-A/B.
 REGION 245 322 Interactions with DUSP26, MAPK1 and
 REGION 364 389 Hydrophobic repeat HR-C.
 MOD_RES 298 298 Phosphoserine.
 CROSSLNK 293 293 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Activator; Alternative splicing; Cataract; Complete proteome; Disease mutation; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repressor; Stress response; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 492 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0048468; P:cell development; IEA:Compara.
 GO:0033169; P:histone H3-K9 demethylation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045597; P:positive regulation of cell differentiation; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0070207; P:protein homotrimerization; IEA:Compara.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000232; HSF_DNA-bd.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00447; HSF_DNA-bind 

SMART

 SM00415; HSF 

PROSITE

 PS00434; HSF_DOMAIN 

PRINTS

 PR00056; HSFDOMAIN.