UniProt Accession

 DRD1_HUMAN; P21728; B2RA44; Q4QRJ0 

Genbank Protein ID

 X55760; X58987; X55758; S58541; AB065677; AF498961; AK314031; CH471062; BC074978; BC074979; BC096837 

Genbank Nucleotide ID

 CAA39286.1; CAA41734.1; CAA39284.1; AAB26273.1; BAC05902.1; AAM18131.1; BAG36741.1; EAW61377.1; AAH74978.1; AAH74979.1; AAH96837.1 

Protein Name

 D(1A) dopamine receptor 

Protein Synonyms/Alias

 Dopamine D1 receptor 

Gene Name

 DRD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
223	RIYRIAQKQIRRIAA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. 

Sequence Annotation

 LIPID 347 347 S-palmitoyl cysteine.
 LIPID 351 351 S-palmitoyl cysteine.
 CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
 DISULFID 96 186 By similarity.  

Keyword

 3D-structure; Cell membrane; Complete proteome; Disulfide bond; Endoplasmic reticulum; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 446 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IC:BHF-UCL.
 GO:0097458; C:neuron part; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0035240; F:dopamine binding; IMP:BHF-UCL.
 GO:0001588; F:dopamine neurotransmitter receptor activity, coupled via Gs; IDA:BHF-UCL.
 GO:0007190; P:activation of adenylate cyclase activity; IDA:BHF-UCL.
 GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IDA:BHF-UCL.
 GO:0007628; P:adult walking behavior; ISS:BHF-UCL.
 GO:0014002; P:astrocyte development; IEA:Compara.
 GO:0001662; P:behavioral fear response; IEA:Compara.
 GO:0048148; P:behavioral response to cocaine; IEA:Compara.
 GO:0071870; P:cellular response to catecholamine stimulus; IDA:BHF-UCL.
 GO:0021853; P:cerebral cortex GABAergic interneuron migration; ISS:BHF-UCL.
 GO:0001661; P:conditioned taste aversion; IEA:Compara.
 GO:0021542; P:dentate gyrus development; IEA:Compara.
 GO:0042417; P:dopamine metabolic process; IC:BHF-UCL.
 GO:0015872; P:dopamine transport; IEA:Compara.
 GO:0051482; P:elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IDA:BHF-UCL.
 GO:0046323; P:glucose import; IEA:Compara.
 GO:0007625; P:grooming behavior; IEA:Compara.
 GO:0060292; P:long term synaptic depression; IEA:Compara.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0007617; P:mating behavior; ISS:BHF-UCL.
 GO:0007613; P:memory; IEA:Compara.
 GO:0035106; P:operant conditioning; IEA:Compara.
 GO:0030432; P:peristalsis; IEA:Compara.
 GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IDA:BHF-UCL.
 GO:0010579; P:positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; IEA:InterPro.
 GO:0030335; P:positive regulation of cell migration; ISS:BHF-UCL.
 GO:0043268; P:positive regulation of potassium ion transport; ISS:BHF-UCL.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:BHF-UCL.
 GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISS:BHF-UCL.
 GO:0060134; P:prepulse inhibition; ISS:BHF-UCL.
 GO:0006606; P:protein import into nucleus; IEA:Compara.
 GO:0019228; P:regulation of action potential in neuron; IEA:Compara.
 GO:0042053; P:regulation of dopamine metabolic process; IEA:Compara.
 GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; IC:BHF-UCL.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0042493; P:response to drug; ISS:BHF-UCL.
 GO:0046960; P:sensitization; IEA:Compara.
 GO:0021756; P:striatum development; IEA:Compara.
 GO:0007416; P:synapse assembly; ISS:BHF-UCL.
 GO:0001963; P:synaptic transmission, dopaminergic; IEA:Compara.
 GO:0001659; P:temperature homeostasis; IEA:Compara.
 GO:0042311; P:vasodilation; IEA:InterPro.
 GO:0008542; P:visual learning; ISS:BHF-UCL. 

Interpro

 IPR001413; Dopamine_D1_rcpt.
 IPR000929; Dopamine_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00565; DOPAMINED1AR.
 PR00242; DOPAMINER.
 PR00237; GPCRRHODOPSN.