| Tag | Content |
|---|
| CPLM ID | CPLM-023428 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
Protein Synonyms/Alias | MCAD |
Gene Name | CG12262 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 416 | RNMYEAAKGQA**** | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | This enzyme is specific for acyl chain lengths of 4 to 16 (By similarity). |
Sequence Annotation | NP_BIND 154 163 FAD (By similarity).
NP_BIND 187 189 FAD (By similarity).
NP_BIND 302 304 FAD (By similarity).
NP_BIND 312 313 FAD (By similarity).
NP_BIND 370 374 FAD (By similarity).
NP_BIND 399 401 FAD (By similarity).
REGION 274 277 Substrate binding (By similarity).
ACT_SITE 397 397 Proton acceptor (By similarity).
BINDING 163 163 Substrate; via carbonyl oxygen (By
BINDING 398 398 Substrate; via amide nitrogen (By |
Keyword | Complete proteome; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 419 AA |
Protein Sequence | MAFLNKLAAP ALRQLVSQSR AYAAVSHVSP NGTSFALTED QLQLQELARK FTREEIIPVA 60
AQYDKSGEYP WPIIKKAWEL GLMNNHIPAD IGGLDLDVFT TCLSAEELAY GCTGIMTALE 120
ASGLGQTPVI LSGNKEQKKK YLGRLLEEPL VAAYCVTEPG AGSDVSGIKT RAEKKGDEWV 180
INGQKMWITN GGVANWYFVL ARTNPDPKCP PSKAFTGFIV ERDSPGLTPG RKELNMGQRA 240
SDTRGITFED VRVPKENVLI GEGAGFKIAM GTFDKTRPPV AAGAVGLAQR CLDEALKYAL 300
ERKTFGVPIA YHQAVQFMLA DMAIGVETSR LAWRLSAWEI DQGRRNSYYA SIAKCHAADM 360
ANKIASDAVQ IFGGNGFNSE YPVEKLMRDA KIYQIYEGTS QIQRLIISRN MYEAAKGQA 419 |
Gene Ontology | GO:0005811; C:lipid particle; IDA:FlyBase. GO:0005875; C:microtubule associated complex; IDA:FlyBase. GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:FlyBase. GO:0003995; F:acyl-CoA dehydrogenase activity; ISS:UniProtKB. GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0006635; P:fatty acid beta-oxidation; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |