CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017342
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 47 
Protein Synonyms/Alias
  
Gene Name
 LRRC47 
Gene Synonyms/Alias
 KIAA1185 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
228LADCPKLKEINFRGNubiquitination[1, 2]
353LQPGNALKRFLTSQTubiquitination[1]
369LHEDLCEKRTAATLAubiquitination[1]
398ARPPQDLKIVPLGRKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 REPEAT 76 95 LRR 1.
 REPEAT 100 121 LRR 2.
 REPEAT 130 152 LRR 3.
 REPEAT 154 175 LRR 4.
 REPEAT 180 202 LRR 5.
 REPEAT 203 225 LRR 6.
 REPEAT 226 246 LRR 7.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 431 431 Phosphoserine.
 MOD_RES 509 509 Phosphotyrosine.
 MOD_RES 520 520 Phosphoserine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 583 AA 
Protein Sequence
MAAAAVSESW PELELAERER RRELLLTGPG LEERVRAAGG QLPPRLFTLP LLHYLEVSGC 60
GSLRAPGPGL AQGLPQLHSL VLRRNALGPG LSPELGPLPA LRVLDLSGNA LEALPPGQGL 120
GPAEPPGLPQ LQSLNLSGNR LRELPADLAR CAPRLQSLNL TGNCLDSFPA ELFRPGALPL 180
LSELAAADNC LRELSPDIAH LASLKTLDLS NNQLSEIPAE LADCPKLKEI NFRGNKLRDK 240
RLEKMVSGCQ TRSILEYLRV GGRGGGKGKG RAEGSEKEES RRKRRERKQR REGGDGEEQD 300
VGDAGRLLLR VLHVSENPVP LTVRVSPEVR DVRPYIVGAV VRGMDLQPGN ALKRFLTSQT 360
KLHEDLCEKR TAATLATHEL RAVKGPLLYC ARPPQDLKIV PLGRKEAKAK ELVRQLQLEA 420
EEQRKQKKRQ SVSGLHRYLH LLDGNENYPC LVDADGDVIS FPPITNSEKT KVKKTTSDLF 480
LEVTSATSLQ ICKDVMDALI LKMAEMKKYT LENKEEGSLS DTEADAVSGQ LPDPTTNPSA 540
GKDGPSLLVV EQVRVVDLEG SLKVVYPSKA DLATAPPHVT VVR 583 
Gene Ontology
 GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR005146; B3/B4_tRNA-bd.
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp. 
Pfam
 PF03483; B3_4
 PF12799; LRR_4 
SMART
 SM00873; B3_4
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR 
PRINTS