UniProt Accession

 S5A1_MOUSE; Q68FF9; Q505K7 

Genbank Protein ID

 BC079863; BC094503 

Genbank Nucleotide ID

 AAH79863.1; AAH94503.1 

Protein Name

 3-oxo-5-alpha-steroid 4-dehydrogenase 1 

Protein Synonyms/Alias

 SR type 1; Steroid 5-alpha-reductase 1; S5AR 1 

Gene Name

 Srd5a1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
180	KPGETGYKIPRGGLF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Differentiation; Endoplasmic reticulum; Membrane; Microsome; NADP; Oxidoreductase; Reference proteome; Sexual differentiation; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 255 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003865; F:3-oxo-5-alpha-steroid 4-dehydrogenase activity; ISS:UniProtKB.
 GO:0047751; F:cholestenone 5-alpha-reductase activity; IEA:EC.
 GO:0006702; P:androgen biosynthetic process; IMP:MGI.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007548; P:sex differentiation; IEA:UniProtKB-KW. 

Interpro

 IPR016636; 3-oxo-5-alpha-steroid_4-DH.
 IPR001104; 3-oxo-5_a-steroid_4-DH_C. 

Pfam

 PF02544; Steroid_dh 

SMART

  

PROSITE

 PS50244; S5A_REDUCTASE 

PRINTS