CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035745
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Arap1 
Protein Synonyms/Alias
  
Gene Name
 Arap1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
390VAAIGDQKFEVITNSacetylation[1]
1036DDVSSALKRFLRDLPacetylation[1]
1339ETSHRPEKEWPVKSLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1454 AA 
Protein Sequence
MAEGHDAALS VAEWLRALHL EQYTALFEQH GLVWATECQG LSDASLVDMG MNLPGHRRRI 60
LAGLHRAHAP PPVPVPRPAP RPVPMKRHIF RSPPVPVTPP EPPPTAGEDQ GLPAAPPIPP 120
RRSCLPPACF TPPSTAPPDP VLPPLPAKRH SVEPSLPPVP PRTGPPYPQT SLLSKEELLL 180
PSVSPWSQPE PTETPSTLLP AFPQGPLQPP SPPPCPPVIP PKPLRLLPEF DDSDYDDVPE 240
EGPGAPASVM TKEEPLPSRV PRAVRVASLL SEGEELSGDD AEDEDDHAYE GIPNGGWPTI 300
GLNPPLSSLI PDLPLHPMDE LPGGSTPTTP VIKAGWLDKN PPQGSYIYQK RWVRLDADHL 360
RYFDSNKDAY SKRFVPVACI CRVAAIGDQK FEVITNSRTF AFRAESDVER NEWMQALQQA 420
VVEHRAHIRL SSASVLGVRG GTEQPDHAGS LELRGFKNKL YVAVAGDKVQ LYKNLEEFHL 480
GIGITFIDMN VGNVKEVDRR SFDLTTPYRI FSFSADSELE KEQWLEAMQG AIAEALSTSE 540
VAERIWAAAP NRFCADCGAA QPDWASINLC IVICKRCAGE HRGLGAGVSK VRSLKMDRKV 600
WTETLIQLFL QLGNGPGNHF WAANVPPSEA LEPSSSPGAR RYHLEAKYRE GKYRRYHPLF 660
GNQEELDKAL CAAVTTTDLA ETQALLGCGA GVNCFSGDPA APTPLALAEQ AGQTLQMEFL 720
RNNQSTEVPR LDSVKPSEKH YSITLPTVSH SGFLYKTASA GKPLQDRRAR EEFSRRWCVL 780
SDGVLSYYEN ERAVTPNGEI RASEIVCLAV SPLDTHGFEH TFEVYTEGER LYLFGLENAE 840
LAHEWVKCIA KAFVPPLAED LLARDFERLG RLPCKAGLSL QQAQEGWFAL TGSELRAVFP 900
EGPWEEPLQL RRLQELSIQG DSENQVLVLV ERRRTLYIQG ERRLDFMAWL GAIQKAAASL 960
GDTLSEQQLG DSDIPVIVYR CIDYITQCGL TSEGIYRKCG QTSKTQRLLD SLRQDARSVH 1020
LKEGEQHVDD VSSALKRFLR DLPDGLFTRA QRLAWLEASE IEDEEEKISR YRELLVHLPP 1080
VNRATVKALI SHLYCVQCFS DTNQMNTHNL AIVFGPTLFQ TDGQDYKAGK VVEDLISHYV 1140
VVFSVDEEEL RKQREEVTAI VKMRVAGTAS GTQHAGDFIC TVYLEEKKVE TEQHVKIPAS 1200
MTAEELTLEI LDRRNVSIRE KDYWTCFEVN EKEEAERPLH FAEKVLPIVH GLGMDSHLVV 1260
KKYPSMEAML LYLASRVGDT KHGMMKFRED RSLLGLGLPS GGFHDRYFIL NSSCLRLYKE 1320
VRSQRPWSGA PETSHRPEKE WPVKSLKVYL GVKKKLRPPT CWGFTVVHET EKHEKQQWYL 1380
CCDTQMELRE WFATFLSVQH DGLVWPSEPS RVSRAVPEVR MGSVSLIPLR GSENEMRRSV 1440
AAFTADPLSL LRHV 1454 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IDA:RGD.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0005802; C:trans-Golgi network; IDA:RGD.
 GO:0008060; F:ARF GTPase activator activity; IEA:Compara.
 GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Compara.
 GO:0005100; F:Rho GTPase activator activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051497; P:negative regulation of stress fiber assembly; IEA:Compara.
 GO:0043089; P:positive regulation of Cdc42 GTPase activity; IEA:Compara.
 GO:0051491; P:positive regulation of filopodium assembly; IEA:Compara.
 GO:0001921; P:positive regulation of receptor recycling; IDA:RGD.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
 GO:0008360; P:regulation of cell shape; IEA:Compara.
 GO:0051270; P:regulation of cellular component movement; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR001164; ArfGAP.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000159; Ras-assoc.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1. 
Pfam
 PF01412; ArfGap
 PF00169; PH
 PF00788; RA
 PF00620; RhoGAP
 PF00536; SAM_1 
SMART
 SM00105; ArfGap
 SM00233; PH
 SM00324; RhoGAP
 SM00454; SAM 
PROSITE
 PS50115; ARFGAP
 PS50003; PH_DOMAIN
 PS50200; RA
 PS50238; RHOGAP
 PS50105; SAM_DOMAIN 
PRINTS
 PR00405; REVINTRACTNG.