| Tag | Content |
|---|
| CPLM ID | CPLM-002627 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal recognition particle receptor subunit alpha |
Protein Synonyms/Alias | SR-alpha; Docking protein alpha; DP-alpha |
Gene Name | SRPR |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 492 | TMVQLFEKGYGKDAA | ubiquitination | [1] | | 589 | IDGIVLTKFDTIDDK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. |
Sequence Annotation | NP_BIND 425 432 GTP (By similarity).
NP_BIND 520 524 GTP (By similarity).
NP_BIND 588 591 GTP (By similarity).
MOD_RES 296 296 Phosphoserine.
MOD_RES 297 297 Phosphoserine.
MOD_RES 298 298 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Endoplasmic reticulum; GTP-binding; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 638 AA |
Protein Sequence | MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE ALTLKYKLDN 60
QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ QSALSLLNGT FDFQNDFLRL 120
LREAEESSKI RAPTTMKKFE DSEKAKKPVR SMIETRGEKP KEKAKNSKKK GAKKEGSDGP 180
LATSKPVPAE KSGLPVGPEN GVELSKEELI RRKREEFIQK HGRGMEKSNK STKSDAPKEK 240
GKKAPRVWEL GGCANKEVLD YSTPTTNGTP EAALSEDINL IRGTGSGGQL QDLDCSSSDD 300
EGAAQNSTKP SATKGTLGGM FGMLKGLVGS KSLSREDMES VLDKMRDHLI AKNVAADIAV 360
QLCESVANKL EGKVMGTFST VTSTVKQALQ ESLVQILQPQ RRVDMLRDIM DAQRRQRPYV 420
VTFCGVNGVG KSTNLAKISF WLLENGFSVL IAACDTFRAG AVEQLRTHTR RLSALHPPEK 480
HGGRTMVQLF EKGYGKDAAG IAMEAIAFAR NQGFDVVLVD TAGRMQDNAP LMTALAKLIT 540
VNTPDLVLFV GEALVGNEAV DQLVKFNRAL ADHSMAQTPR LIDGIVLTKF DTIDDKVGAA 600
ISMTYITSKP IVFVGTGQTY CDLRSLNAKA VVAALMKA 638 |
Gene Ontology | GO:0016021; C:integral to membrane; TAS:ProtInc. GO:0005785; C:signal recognition particle receptor complex; TAS:ProtInc. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0005047; F:signal recognition particle binding; TAS:ProtInc. GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome. GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome. GO:0006412; P:translation; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |