UniProt Accession

 SCX7_TITSE; P15226 

Genbank Protein ID

 X66256; S66941 

Genbank Nucleotide ID

 CAA46982.1; AAB29128.1 

Protein Name

 Beta-mammal/insect toxin Ts1 

Protein Synonyms/Alias

 PT-Mice-Ins-beta NaTx6.1; Tityustoxin VII; Ts VII; TsTX-VII; Toxin II-11; Toxin III-10; Toxin T2-IV; Toxin gamma; Ts7 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Tityus serrulatus (Brazilian scorpion) 

NCBI Taxa ID

 6887 

Lysine Modification

Position	Peptide	Type	References
32	LMDHEGCKLSCFIRP	acetylation	[1]

Reference

 [1] Role of lysine and tryptophan residues in the biological activity of toxin VII (Ts gamma) from the scorpion Tityus serrulatus.
 Hassani O, Mansuelle P, Cestèle S, Bourdeaux M, Rochat H, Sampieri F.
 Eur J Biochem. 1999 Feb;260(1):76-86. [PMID: 10091586] 

Functional Description

 Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against both mammals and insects. 

Sequence Annotation

 MOD_RES 81 81 Cysteine amide.
 DISULFID 31 81
 DISULFID 35 57
 DISULFID 43 62
 DISULFID 47 64  

Keyword

 3D-structure; Amidation; Direct protein sequencing; Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Sodium channel inhibitor; Toxin. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 84 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0019871; F:sodium channel inhibitor activity; IEA:UniProtKB-KW.
 GO:0006952; P:defense response; IEA:InterPro. 

Interpro

 IPR003614; Scorpion_toxin-like.
 IPR018218; Scorpion_toxinL.
 IPR002061; Scorpion_toxinL/defesin. 

Pfam

 PF00537; Toxin_3 

SMART

 SM00505; Knot1 

PROSITE

  

PRINTS

 PR00285; SCORPNTOXIN.