CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023074
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FAM208A 
Protein Synonyms/Alias
 CTCL tumor antigen se89-1; Retinoblastoma-associated protein RAP140 
Gene Name
 FAM208A 
Gene Synonyms/Alias
 C3orf63; KIAA1105 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
197QVQTICEKGLHVGQSubiquitination[1, 2]
266SLESMLNKSALDPTPubiquitination[3, 4]
281KHECHVSKNANRITSubiquitination[3]
353NTDRNIDKYNYTLWKubiquitination[3]
360KYNYTLWKGQLLNKGubiquitination[1, 2]
413IPPALFYKETYLGPNubiquitination[3]
424LGPNEVLKNGMYCSLubiquitination[5]
450NMESLLQKLDREKLVubiquitination[3, 5, 6]
460REKLVLVKPLGDRGYubiquitination[1, 2, 3]
507RSIVTSQKGSTNAAPubiquitination[3, 4, 5, 6]
563KYVSEFFKRGFGSGKubiquitination[1, 2]
628ELFEENRKLQQFSPLubiquitination[3]
649EEEMNGTKMKFGKRNubiquitination[3]
667GEAIISGKQRSSHSLubiquitination[3]
682DYDKDRVKELINLIQubiquitination[3]
713SKTVLKRKLEDLPENubiquitination[3, 4]
795SLTDTVNKALGLSTDubiquitination[6]
811AYEELRQKHEYELNSubiquitination[4]
832YEQPTCAKVENAQFKubiquitination[3, 4]
1397TLLNVYQKKHLVEILubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 633 633 Phosphoserine.
 MOD_RES 636 636 Phosphoserine.
 MOD_RES 927 927 Phosphoserine.
 MOD_RES 979 979 Phosphoserine.
 MOD_RES 982 982 Phosphothreonine.
 MOD_RES 1103 1103 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1670 AA 
Protein Sequence
MATAVETEAC QPTDASWESG GGGDDEMKQA LPELESSQQN GGGGGLNIAE PSGGAGREEN 60
AGAEAAQSLS HEQPQDSSEA GAAALPRGPE EPERPVRRSF QIPRKSREKK ALFQPLTPGS 120
REFEDVVNIL HSSYLEPTSV TNFNYRRACL VHNELLEKEF TEKRRELKFD GRLDKELSES 180
YAFLMVDRYQ VQTICEKGLH VGQSKITILG SPSMGVYLSR YADLLQANPL DTGAMGDVVI 240
FKIMKGKIKS IYDPMGVKSL ESMLNKSALD PTPKHECHVS KNANRITSLL AYRAYELTQY 300
YFYEYGFDEL RRRPRHVCPY AVVSFTYKDD IQTPKFVPSS RSNSFNTDRN IDKYNYTLWK 360
GQLLNKGKLL CYISLRSATR AFLPIKLPEK LDVETVMSID HLKQKIPPAL FYKETYLGPN 420
EVLKNGMYCS LYEVVEKTRI GSNMESLLQK LDREKLVLVK PLGDRGYLFL LSPYQMVPPY 480
EYQTAKSRVL HALFLFQEPR SIVTSQKGST NAAPQERHES MPDVLKIAQF LQFSLIQCRK 540
EFKNISAINF HSVVEKYVSE FFKRGFGSGK REFIMFPYDS RLDDKKFLYS APRNKSHIDT 600
CLHAYIFRPE VYQLPICKLK ELFEENRKLQ QFSPLSDYEG QEEEMNGTKM KFGKRNNSRG 660
EAIISGKQRS SHSLDYDKDR VKELINLIQC RKKSVGGDSD TEDMRSKTVL KRKLEDLPEN 720
MRKLAKTSNL SENCHLYEES PQPIGSLGHD ADLRRQQQDT CNSGIADIHR LFNWLSETLA 780
NARHSDASLT DTVNKALGLS TDDAYEELRQ KHEYELNSTP DKKDYEQPTC AKVENAQFKG 840
TQSLLLEVDA TSKYSVAIST SEVGTDHKLH LKEDPNLISV NNFEDCSLCP SVPIEHGFRR 900
QQSKSNNVEE TEIHWKLIPI TGGNARSPED QLGKHGEKQT PGMKSPEEQL VCVPPQEAFP 960
NDPRVINRQR SSDYQFPSSP FTDTLKGTTE DDVLTGQVEE QCVPAAEAEP PAVSETTERT 1020
VLGEYNLFSR KIEEILKQKN VSYVSTVSTP IFSTQEKMKR LSEFIYSKTS KAGVQEFVDG 1080
LHEKLNTIII KASAKGGNLP PVSPNDSGAK IASNPLERHV IPVSSSDFNN KHLLEPLCSD 1140
PLKDTNSDEQ HSTSALTEVE MNQPQHATEL MVTSDHIVPG DMAREPVEET TKSPSDVNIS 1200
AQPALSNFIS QLEPEVFNSL VKIMKDVQKN TVKFYIHEEE ESVLCKEIKE YLIKLGNTEC 1260
HPEQFLERRS KLDKLLIIIQ NEDIAGFIHK IPGLVTLKKL PCVSFAGVDS LDDVKNHTYN 1320
ELFVSGGFIV SDESILNPEV VTVENLKNFL TFLEELSTPE GKWQWKVHCK FQKKLKELGR 1380
LNAKALSLLT LLNVYQKKHL VEILSYHNCD SQTRNAPELD CLIRLQAQNI QQRHIVFLTE 1440
KNIKMLSSYT DNGIVVATAE DFMQNFKNLV GYHNSITEEN LPQLGANENL ESQSALLEND 1500
EKDEEDMSLD SGDEISHIEV CSNFHSEIWE KETKGSRGTD QKKNTQIELQ SSPDVQNSLL 1560
EDKTYLDSEE RTSIDIVCSE GENSNSTEQD SYSNFQVYHS QLNMSHQFSH FNVLTHQTFL 1620
GTPYALSSSQ SQENENYFLS AYTESLDRDK SPPPLSWGKS DSSRPYSQEK 1670 
Gene Ontology
  
Interpro
 IPR022188; DUF3715. 
Pfam
 PF12509; DUF3715 
SMART
  
PROSITE
  
PRINTS