UniProt Accession

 SRSF5_RAT; Q09167; O35335 

Genbank Protein ID

 L13635; AF020683; BC058479; L33267 

Genbank Nucleotide ID

 AAA62266.1; AAB71864.1; AAH58479.1; AAA42316.1 

Protein Name

 Serine/arginine-rich splicing factor 5 

Protein Synonyms/Alias

 Delayed-early protein HRS; Insulin-induced growth response protein CL-4; Pre-mRNA-splicing factor SRP40; Splicing factor, arginine/serine-rich 5 

Gene Name

 Srsf5 

Gene Synonyms/Alias

 Cl-4; Hrs; Sfrs5 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
25	KDVERFFKGYGRIRD	acetylation	[1]
36	RIRDIDLKRGFGFVE	acetylation	[1]
163	DLKNAIEKLSGKEIN	acetylation	[1]
167	AIEKLSGKEINGRKI	acetylation	[1]
175	EINGRKIKLIEGSKR	acetylation	[1]
181	IKLIEGSKRHRSRSR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre- mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity). Could play an important role in development and differentiation in the spleen and thymus. 

Sequence Annotation

 DOMAIN 4 74 RRM 1.
 DOMAIN 108 181 RRM 2.
 MOD_RES 167 167 N6-acetyllysine (By similarity).
 MOD_RES 224 224 Phosphoserine (By similarity).
 MOD_RES 226 226 Phosphoserine (By similarity).
 MOD_RES 228 228 Phosphoserine (By similarity).
 MOD_RES 230 230 Phosphoserine (By similarity).
 MOD_RES 245 245 Phosphoserine (By similarity).
 MOD_RES 247 247 Phosphoserine (By similarity).
 MOD_RES 250 250 Phosphoserine (By similarity).
 MOD_RES 260 260 Phosphoserine (By similarity).
 MOD_RES 262 262 Phosphoserine (By similarity).
 MOD_RES 264 264 Phosphoserine (By similarity).
 MOD_RES 267 267 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0016607; C:nuclear speck; ISS:UniProtKB.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0051726; P:regulation of cell cycle; IEP:RGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS