CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013851
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 pre-rRNA processing protein FTSJ3 
Protein Synonyms/Alias
 2'-O-ribose RNA methyltransferase SPB1 homolog; Protein ftsJ homolog 3; Putative rRNA methyltransferase 3 
Gene Name
 Ftsj3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
214DAKFFDPKFAFKEVEubiquitination[1]
570PPPPTNLKTEKKSSQacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation (By similarity). 
Sequence Annotation
 ACT_SITE 157 157 Proton acceptor (By similarity).
 BINDING 56 56 S-adenosyl-L-methionine; via amide
 BINDING 58 58 S-adenosyl-L-methionine; via amide
 BINDING 76 76 S-adenosyl-L-methionine (By similarity).
 BINDING 92 92 S-adenosyl-L-methionine (By similarity).
 BINDING 117 117 S-adenosyl-L-methionine (By similarity).
 MOD_RES 333 333 Phosphoserine (By similarity).
 MOD_RES 335 335 Phosphoserine (By similarity).
 MOD_RES 336 336 Phosphoserine (By similarity).
 MOD_RES 345 345 Phosphoserine (By similarity).
 MOD_RES 353 353 Phosphoserine (By similarity).
 MOD_RES 368 368 Phosphothreonine (By similarity).
 MOD_RES 544 544 Phosphoserine (By similarity).
 MOD_RES 575 575 Phosphoserine (By similarity).
 MOD_RES 659 659 Phosphoserine (By similarity).
 MOD_RES 671 671 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Methyltransferase; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis; rRNA processing; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 829 AA 
Protein Sequence
MGKKGKVGKS RRDKFYHLAK ETGYRSRSAF KLIQLNRRFQ FLQKARALLD LCAAPGGWLQ 60
VAAKFMPVSS LIVGVDLVPI KPLPNVVTLQ EDITTERCRQ ALRKELKTWK VDVVLNDGAP 120
NVGASWVHDA YSQAHLTLMA LRLACDFLAR GGCFITKVFR SRDYQPLLWI FQQLFHRVQA 180
TKPQASRHES AEIFVVCQGF LAPDKVDAKF FDPKFAFKEV EVQAKTVTEL VTKKKPKAEG 240
YAEGDLTLYH RTSVTDFLRA ANPVDFLSKA SEISIDDKEL AQHPATTEDI RACCQDIKVL 300
GRKELRSLLN WRTKLRRYVA KKLKEQAKAL DISLSSEEEG DEEESAAETK QASEEEEERE 360
EEEQLNRTLA EMKAQEVAEL KRKKKKLLRE QRKQRERVEL KMDLPGVSIA DEGETGMFSL 420
RTIRGQQLLE EVTQGDMNAA DTFLSDLPRD DIYVSDAEDD DDTSLESDLD PEELAGVRTH 480
SDQKEQKSLQ FAQVDDSKEE EGENPLLVPL EEKAVLQEEQ ASLWFSKDGF SGIDDDADEA 540
LEISQAQLLY KSRQKEQQPT DPPPPPTNLK TEKKSSQCQN EVPKETEAIT DTGGEDRDSS 600
DSDSSSSEDE DDWKVSRGKK RSRGSKADED GFEVVPIEDP VKYRILDPEG LALGAVIASS 660
KKAKRDLIDN SFNRYAFNEE EEELPEWFVQ EEKQHRIRQL PLDKKEVEHY RKRWREINAR 720
PIKKVAEAKA RKKRRMLKKL EQTKKKAEAV VNTVDISERE KVAQLRSLYK KAGLGKEKRQ 780
VTYVVAKKGV GRKVRRPAGV RGHFKVVDSR MKKDQRAQRK EQKRNHRRK 829 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0001510; P:RNA methylation; IEA:InterPro.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR015507; rRNA-MeTfrase_E.
 IPR012920; rRNA_MeTfrase_Spb1_C.
 IPR024576; rRNA_MeTfrase_Spb1_DUF3381.
 IPR002877; rRNA_MeTrfase_FtsJ_dom. 
Pfam
 PF11861; DUF3381
 PF01728; FtsJ
 PF07780; Spb1_C 
SMART
  
PROSITE
  
PRINTS