CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016686
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Enhancer of polycomb homolog 2 
Protein Synonyms/Alias
 EPC-like 
Gene Name
 Epc2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
23PLPIYRGKDMPDLNDacetylation[1, 2]
677VQPSGPSKTLYSTNMacetylation[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 May play a role in transcription or DNA repair (By similarity). 
Sequence Annotation
  
Keyword
 Chromatin regulator; Complete proteome; DNA damage; DNA repair; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 808 AA 
Protein Sequence
MSKLSFRARA LDAAKPLPIY RGKDMPDLND CVSINRAVPQ MPTGMEKEEE SEHHLQRAIS 60
AQQVFREKKE SMVIPVPEAE SNVNYYNRLY KGEFKQPKQF IHIQPFNLDN EQPDYDMDSE 120
DETLLNRLNR KMEIKPLQFE IMIDRLEKAS SNQLVTLQEA KLLLNEDDYL IKAVYDYWVR 180
KRKNCRGPSL IPQIKQEKRD GSTNNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRE 240
FSRAITILEM IKRREKTKRE LLHLTLEVVE KRYHLGDYGG EILNEVKVNR SEKELYASPA 300
TLHNGNHHKV QECKTKHPHH LSLKEEASDV VRQKKKYPKK PKAEAGIAPQ QPTPETLPVI 360
NKSDIKQYDF QSSDEDEFPQ VLSPASEAEE ENDPDGSCAF RRRAGCQYYA PRLDQANNHM 420
CENSELADLD KLRYKHCLTT LTVPRRCIGF ARRRIGRGGR VIMDRISTEH DPVLKQIDPE 480
MLNGFSSSSQ TIDFSSNFSR TNASSKPCEN RLSLSEILSN IRSCRLQCFQ PRLLNVQDID 540
SEECTSRKPG QTVSSKRVSA ASVALLNTSK NGISVTGGIT EEQFQTHQQQ LVQMQRQQLA 600
QLHQKQQSQH SSQQTHPKAQ GSSTSDCMSK TLDSASAHFA ASAVVSAPVP SRSEGSKEQN 660
TGHNNMNGVV QPSGPSKTLY STNMALSSSP GISAVQLVRT VGHTTTNHLI PALCTSSPQT 720
LPMNNSCLTN AVHLNNVSVV SPVNVHINTR TSAPSPTALK LATVAASMDR VPKVTPSSAI 780
SSIARENHEP ERLGLNGLAE TTVAMEVT 808 
Gene Ontology
 GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; IEA:InterPro.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR024943; Enhancer_polycomb.
 IPR019542; Enhancer_polycomb-like_N.
 IPR009607; Enhancer_polycomb_C. 
Pfam
 PF06752; E_Pc_C
 PF10513; EPL1 
SMART
  
PROSITE
  
PRINTS