UniProt Accession

 TACD2_MOUSE; Q8BGV3; O55130 

Genbank Protein ID

 Y08830; AK076410; AK077370; AK085753; CH466523; BC117719; BC117720 

Genbank Nucleotide ID

 CAA70063.1; BAC36328.1; BAC36773.1; BAC39531.1; EDK98807.1; AAI17720.1; AAI17721.1 

Protein Name

 Tumor-associated calcium signal transducer 2 

Protein Synonyms/Alias

 Cell surface glycoprotein Trop-2 

Gene Name

 Tacstd2 

Gene Synonyms/Alias

 Trop2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
306	KYKKVELKELGEMRS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May function as a growth factor receptor (By similarity). 

Sequence Annotation

 DOMAIN 64 139 Thyroglobulin type-1.
 CARBOHYD 27 27 N-linked (GlcNAc...) (Potential).
 CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
 CARBOHYD 162 162 N-linked (GlcNAc...) (Potential).
 CARBOHYD 202 202 N-linked (GlcNAc...) (Potential).
 DISULFID 67 102 By similarity.
 DISULFID 113 119 By similarity.
 DISULFID 121 139 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0009925; C:basal plasma membrane; IDA:UniProtKB.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016328; C:lateral plasma membrane; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0090191; P:negative regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
 GO:0010633; P:negative regulation of epithelial cell migration; IDA:UniProtKB.
 GO:1900028; P:negative regulation of ruffle assembly; IDA:UniProtKB.
 GO:0051497; P:negative regulation of stress fiber assembly; IDA:UniProtKB.
 GO:1900025; P:negative regulation of substrate adhesion-dependent cell spreading; IDA:UniProtKB.
 GO:2000738; P:positive regulation of stem cell differentiation; IDA:MGI.
 GO:0050678; P:regulation of epithelial cell proliferation; IEP:UniProtKB.
 GO:0060675; P:ureteric bud morphogenesis; IEP:UniProtKB. 

Interpro

 IPR000716; Thyroglobulin_1. 

Pfam

 PF00086; Thyroglobulin_1 

SMART

 SM00211; TY 

PROSITE

 PS00484; THYROGLOBULIN_1_1
 PS51162; THYROGLOBULIN_1_2 

PRINTS