CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035712
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alpha-1-inhibitor 3 
Protein Synonyms/Alias
  
Gene Name
 A1i3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
181IMQWQDVKTENGLKQacetylation[1]
365HGIPFFVKVRLVDIKacetylation[1]
372KVRLVDIKGDPIPNEacetylation[1]
384PNEQVLIKARDAGYTacetylation[1]
1296SQKFQVDKSNRLLLQacetylation[1]
1338RYNVPLEKQQPAFALacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1476 AA 
Protein Sequence
MKKDREAQLC LFSALLAFLP FASLLNGNSK YMVLVPSQLY TETPEKICLH LYHLNETVTV 60
TASLISQRGT RKLFDELVVD KDLFHCVSFT IPRLPSSEEE ESLDINIEGA KHKFSERRVV 120
LVKNKESVVF VQTDKPMYKP GQSVKFRVVS MDKNLHPLNE LVVFYLWDPK MNRIMQWQDV 180
KTENGLKQLS FSLSAEPIQG PYKIVILKQS GVKEEHSFTV MEFVLPRFGV DVKVPNAISV 240
YDEIINVTAC ATYTYGKPVP GHVKISLCHG NPTFSSETKS ACKEEDSRLD NNGCSTQEVN 300
ITEFQLKENY LKMHQAFHVN ATVTEEGTGS EFSGSGRIEV ERTRNKFLFL KADSHFRHGI 360
PFFVKVRLVD IKGDPIPNEQ VLIKARDAGY TNATTTDQHG LAKFSIDTSG ISDYSLNIKV 420
YHKEESSCIH SSCTAERHAE AHHTAYAVYS LSKSYIYLDT EAGVLPCNQI HTVQAHFILK 480
GQVLGVLQQI VFHYLVMAQG SILQTGNHTH QVEPGESQVQ GNFALEIPVE FSMVPVAKML 540
IYTILPDGEV IADSVKFQVE KCLRNKVQLS FSPSQSLPAS QTHMRVTASP QSLCGLRAVD 600
QSVLLQKPEA ELSPSLIYDL PGMQDSNFIA SSNDPFEDED YCLMYQPIAR EKDVYRYVRE 660
TGLMAFTNLK IKLPTYCNTD YDMVPLAVPA VALDSSTDRG MYESLPVVAV KSPLPQEPPR 720
KDPPPKDPVI ETIRNYFPET WIWDLVTVNS SGVTELEMTV PDTITEWKAG ALCLSNDTGL 780
GLSSVASFQA FQPFFVELTM PYSVIRGEAF TLKATVLNYL PTSLPMAVLL EASPDFTAVP 840
VENNQDSYCL GANGRHTSSW LVTPKSLGNV NFSVSAEARQ SPGPCGSEVA TVPETGRKDT 900
VVKVLIVEPE GIKKEHTFSS LLCASDAELS ETLSLLLPPT VVKDSARAHF SVMGDILSSA 960
IKNTQNLIQM PYGCGEQNMV LFAPNIYVLK YLNETQQLTE KIKSKALGYL RAGYQRELNY 1020
KHKDGSYSAF GDHNGQGQGN TWLTAFVLKS FAQARAFIFI DESHITDAFT WLSKQQKDSG 1080
CFRSSGSLLN NAMKGGVDDE ITLSAYITMA LLESSLPDTK PTKSEALSCL ESSWENIEQG 1140
GNGSFVYTKA LMAYAFALAG NQEKRNEILK SLDKEAIKED NSIHWERPQK PTKSEGYLYT 1200
PQASSAEVEM SAYVVLARLT AQPAPSPEDL ALSMGTIKWL TKQQNSYGGF SSTQDTVVAL 1260
DALSKYGAAT FSKSQKTPSV TVQSSGSFSQ KFQVDKSNRL LLQQVSLPYI PGNYTVSVSG 1320
EGCVYAQTTL RYNVPLEKQQ PAFALKVQTV PLTCNNPKGQ NSFQISLEIS YTGSRPASNM 1380
VIADVKMLSG FIPLKPTVKK LERLGHVSRT EVTTNNVLLY LDQVTNQTLS FSFIIQQDIP 1440
VKNLQPAIVK VYDYYETDEV AFAEYSSPCS SDDQNV 1476 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:InterPro.
 GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
 GO:0010951; P:negative regulation of endopeptidase activity; IEA:GOC. 
Interpro
 IPR009048; A-macroglobulin_rcpt-bd.
 IPR011626; A2M_comp.
 IPR002890; A2M_N.
 IPR011625; A2M_N_2.
 IPR001599; Macroglobln_a2.
 IPR019742; MacrogloblnA2_CS.
 IPR019565; MacrogloblnA2_thiol-ester-bond.
 IPR008930; Terpenoid_cyclase/PrenylTrfase.
 IPR010916; TonB_box_CS. 
Pfam
 PF00207; A2M
 PF07678; A2M_comp
 PF01835; A2M_N
 PF07703; A2M_N_2
 PF07677; A2M_recep
 PF10569; Thiol-ester_cl 
SMART
  
PROSITE
 PS00477; ALPHA_2_MACROGLOBULIN
 PS00430; TONB_DEPENDENT_REC_1 
PRINTS