CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011239
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Activin receptor type-1 
Protein Synonyms/Alias
 Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I 
Gene Name
 ACVR1 
Gene Synonyms/Alias
 ACVRLK2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
446PSFEDMRKVVCVDQQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). 
Sequence Annotation
 DOMAIN 178 207 GS.
 DOMAIN 208 502 Protein kinase.
 NP_BIND 214 222 ATP (By similarity).
 ACT_SITE 336 336 Proton acceptor (By similarity).
 BINDING 235 235 ATP (By similarity).
 MOD_RES 501 501 Phosphoserine.
 CARBOHYD 102 102 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; ATP-binding; Complete proteome; Disease mutation; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN 60
DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 120
HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 180
ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 240
DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300
DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 360
HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 420
NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 480
NPSARLTALR IKKTLTKIDN SLDKLKTDC 509 
Gene Ontology
 GO:0048179; C:activin receptor complex; IDA:UniProtKB.
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0048185; F:activin binding; IDA:UniProtKB.
 GO:0016361; F:activin receptor activity, type I; IEA:Compara.
 GO:0005524; F:ATP binding; IDA:HGNC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0017046; F:peptide hormone binding; NAS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:HGNC.
 GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:Compara.
 GO:0046332; F:SMAD binding; IDA:HGNC.
 GO:0050431; F:transforming growth factor beta binding; IDA:UniProtKB.
 GO:0005025; F:transforming growth factor beta receptor activity, type I; IEA:Compara.
 GO:0032924; P:activin receptor signaling pathway; IDA:BHF-UCL.
 GO:0002526; P:acute inflammatory response; IEA:Compara.
 GO:0003289; P:atrial septum primum morphogenesis; IMP:BHF-UCL.
 GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.
 GO:0060923; P:cardiac muscle cell fate commitment; IMP:BHF-UCL.
 GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Compara.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0003143; P:embryonic heart tube morphogenesis; IMP:BHF-UCL.
 GO:0061445; P:endocardial cushion cell fate commitment; IMP:BHF-UCL.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:HGNC.
 GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0003183; P:mitral valve morphogenesis; IMP:BHF-UCL.
 GO:0032926; P:negative regulation of activin receptor signaling pathway; IMP:HGNC.
 GO:0043066; P:negative regulation of apoptotic process; IMP:HGNC.
 GO:0001755; P:neural crest cell migration; IEA:Compara.
 GO:0060389; P:pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.
 GO:0001569; P:patterning of blood vessels; IEA:Compara.
 GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.
 GO:0060037; P:pharyngeal system development; IEA:Compara.
 GO:0030501; P:positive regulation of bone mineralization; IMP:BHF-UCL.
 GO:2000017; P:positive regulation of determination of dorsal identity; IDA:BHF-UCL.
 GO:0045669; P:positive regulation of osteoblast differentiation; IMP:BHF-UCL.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0048641; P:regulation of skeletal muscle tissue development; IEA:Compara.
 GO:0051145; P:smooth muscle cell differentiation; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
 GO:0001655; P:urogenital system development; IEA:Compara. 
Interpro
 IPR000333; Activin_II/TGFBeta-II_recpt.
 IPR000472; Activin_rcpt.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS.
 IPR003605; TGF_beta_rcpt_GS. 
Pfam
 PF01064; Activin_recp
 PF00069; Pkinase
 PF08515; TGF_beta_GS 
SMART
 SM00467; GS 
PROSITE
 PS51256; GS
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS
 PR00653; ACTIVIN2R.