UniProt Accession

 HAUS7_HUMAN; Q99871; B4DUH6; D3DWT9; Q96HS8; Q9NP54; Q9UFH9 

Genbank Protein ID

 U82695; CH471172; CH471172; CH471172; CH471172; BC008141; CA441020; AK300650; AF267739; X99270; AL122036 

Genbank Nucleotide ID

 EAW72866.1; EAW72868.1; EAW72869.1; EAW72871.1; AAH08141.3; BAG62338.1; AAF75785.1; CAA67665.1; CAB59176.1 

Protein Name

 HAUS augmin-like complex subunit 7 

Protein Synonyms/Alias

 26S proteasome-associated UCH37-interacting protein 1; UCHL5-interacting protein; X-linked protein STS1769 

Gene Name

 HAUS7 

Gene Synonyms/Alias

 UCHL5IP; UIP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
98	QDRFSSLKGVPTEVK	ubiquitination	[1]
111	VKIQEMTKLGHELML	ubiquitination	[2]
128	PDDQELLKGCACAQK	ubiquitination	[2, 3]
135	KGCACAQKQLHFMDQ	ubiquitination	[2, 3]
218	QWASASAKSEEEEKL	ubiquitination	[1]
224	AKSEEEEKLAELARQ	ubiquitination	[1]
267	DISTLDQKLRLVTSD	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. 

Sequence Annotation

 MOD_RES 26 26 Phosphoserine.  

Keyword

 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 368 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0070652; C:HAUS complex; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0031996; F:thioesterase binding; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051297; P:centrosome organization; IMP:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0051225; P:spindle assembly; IMP:UniProtKB. 

Interpro

  

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SMART

  

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PRINTS