CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014969
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADNP homeobox protein 2 
Protein Synonyms/Alias
 Zinc finger protein 508 
Gene Name
 ADNP2 
Gene Synonyms/Alias
 KIAA0863; ZNF508 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89TKVLTSFKNHLHRYHubiquitination[1]
199EEMGEQPKTNDTVSIubiquitination[2]
246IHRDLENKLRSVISEubiquitination[1]
256SVISEHIKRTGLLKQubiquitination[1]
731GEKLEPEKLAACAPFubiquitination[1]
740AACAPFLKWMREKTVubiquitination[1]
797RNRHLGKKKLPMDYSubiquitination[1]
798NRHLGKKKLPMDYSNubiquitination[1]
872GTPGSTGKRVSTCPFubiquitination[1, 2]
979SSFSVKRKLPDGHLGubiquitination[1]
1018VTSVVPFKRQRNESRubiquitination[1]
1032RTEGPIVKDEALQILubiquitination[1, 2]
1055GRSYEEKKQFLKDYFubiquitination[1]
1059EEKKQFLKDYFHKKPubiquitination[1]
1093DVASFFGKRRYICMKubiquitination[1, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 ZN_FING 73 96 C2H2-type 1.
 ZN_FING 215 240 C2H2-type 2.
 ZN_FING 770 793 C2H2-type 3.
 ZN_FING 875 905 C2H2-type 4.
 DNA_BIND 1043 1102 Homeobox.
 MOD_RES 1024 1024 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Homeobox; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1131 AA 
Protein Sequence
MFQIPVENLD NIRKVRKKVK GILVDIGLDS CKELLKDLKG FDPGEKYFHN TSWGDVSLWE 60
PSGKKVRYRT KPYCCGLCKY STKVLTSFKN HLHRYHEDEI DQELVIPCPN CVFASQPKVV 120
GRHFRMFHAP VRKVQNYTVN ILGETKSSRS DVISFTCLKC NFSNTLYYSM KKHVLVAHFH 180
YLINSYFGLR TEEMGEQPKT NDTVSIEKIP PPDKYYCKKC NANASSQDAL MYHILTSDIH 240
RDLENKLRSV ISEHIKRTGL LKQTHIAPKP AAHLAAPANG SAPSAPAQPP CFHLALPQNS 300
PSPAAGQPVT VAQGAPGSLT HSPPAAGQSH MTLVSSPLPV GQNSLTLQPP APQPVFLSHG 360
VPLHQSVNPP VLPLSQPVGP VNKSVGTSVL PINQTVRPGV LPLTQPVGPI NRPVGPGVLP 420
VSPSVTPGVL QAVSPGVLSV SRAVPSGVLP AGQMTPAGQM TPAGVIPGQT ATSGVLPTGQ 480
MVQSGVLPVG QTAPSRVLPP GQTAPLRVIS AGQVVPSGLL SPNQTVSSSA VVPVNQGVNS 540
GVLQLSQPVV SGVLPVGQPV RPGVLQLNQT VGTNILPVNQ PVRPGASQNT TFLTSGSILR 600
QLIPTGKQVN GIPTYTLAPV SVTLPVPPGG LATVAPPQMP IQLLPSGAAA PMAGSMPGMP 660
SPPVLVNAAQ SVFVQASSSA ADTNQVLKQA KQWKTCPVCN ELFPSNVYQV HMEVAHKHSE 720
SKSGEKLEPE KLAACAPFLK WMREKTVRCL SCKCLVSEEE LIHHLLMHGL GCLFCPCTFH 780
DIKGLSEHSR NRHLGKKKLP MDYSNRGFQL DVDANGNLLF PHLDFITILP KEKLGEREVY 840
LAILAGIHSK SLVPVYVKVR PQAEGTPGST GKRVSTCPFC FGPFVTTEAY ELHLKERHHI 900
MPTVHTVLKS PAFKCIHCCG VYTGNMTLAA IAVHLVRCRS APKDSSSDLQ AQPGFIHNSE 960
LLLVSGEVMH DSSFSVKRKL PDGHLGAEDQ RHGEEQPPIL NADAAPGPEK VTSVVPFKRQ 1020
RNESRTEGPI VKDEALQILA LDPKKYEGRS YEEKKQFLKD YFHKKPYPSK KEIELLSSLF 1080
WVWKIDVASF FGKRRYICMK AIKNHKPSVL LGFDMSELKN VKHRLNFEYE P 1131 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0034599; P:cellular response to oxidative stress; ISS:UniProtKB.
 GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
 GO:0060548; P:negative regulation of cell death; ISS:UniProtKB.
 GO:0030182; P:neuron differentiation; ISS:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like. 
Pfam
  
SMART
 SM00389; HOX
 SM00355; ZnF_C2H2 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS