UniProt Accession

 MO4L1_HUMAN; Q9UBU8; B4DKN6; B7Z6R1; D3DW88; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5 

Genbank Protein ID

 AF100615; AF167173; AF218011; AY148481; AF070664; AF161546; AF109188; AK296650; AK300789; AL137697; AC011944; AC022748; AC103975; CH471136; CH471136; CH471136; CH471136; BC022845; BC002936; BC067826; CX165647; AF131847 

Genbank Nucleotide ID

 AAD29872.1; AAF80854.1; AAG17253.1; AAN65338.1; AAD20970.1; AAF29033.1; AAQ13497.1; BAG59248.1; BAH13347.1; CAB70879.2; EAW99145.1; EAW99144.1; EAW99146.1; EAW99147.1; AAH22845.1; AAH02936.1; AAH67826.1; AAD20058.1 

Protein Name

 Mortality factor 4-like protein 1 

Protein Synonyms/Alias

 MORF-related gene 15 protein; Protein MSL3-1; Transcription factor-like protein MRG15 

Gene Name

 MORF4L1 

Gene Synonyms/Alias

 MRG15; FWP006; HSPC008; HSPC061; PP368 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
72	YVDTNLQKQRELQKA	ubiquitination	[1]
78	QKQRELQKANQEQYA	ubiquitination	[1]
88	QEQYAEGKMRGAAPG	ubiquitination	[1]
104	KTSGLQQKNVEVKTK	ubiquitination	[1]
165	VKIPEELKPWLVDDW	ubiquitination	[1]
187	QLFYLPAKKNVDSIL	ubiquitination	[1, 2]
201	LEDYANYKKSRGNTD	ubiquitination	[1]
210	SRGNTDNKEYAVNEV	ubiquitination	[1]
300	DFLKYLAKNSATLFS	ubiquitination	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. 

Sequence Annotation

 DOMAIN 191 362 MRG.
 REGION 26 62 Interaction with KAT8.
 REGION 133 266 Sufficient for interaction with SIN3A.
 REGION 164 230 Interaction with RB1-1.
 REGION 188 342 Sufficient for interaction with PHF12.
 REGION 323 344 Interaction with RB1-2.
 MOTIF 135 146 Nuclear localization signal (Potential).
 MOD_RES 143 143 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Chromatin regulator; Complete proteome; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; Growth regulation; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB.
 GO:0016580; C:Sin3 complex; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0000724; P:double-strand break repair via homologous recombination; IDA:UniProtKB.
 GO:0016575; P:histone deacetylation; IDA:UniProtKB.
 GO:0043968; P:histone H2A acetylation; IDA:UniProtKB.
 GO:0043967; P:histone H4 acetylation; IDA:UniProtKB.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016197; Chromodomain-like.
 IPR017398; EAF3/MRG15.
 IPR008676; MRG.
 IPR026541; MRG_dom.
 IPR025995; Tudor-knot. 

Pfam

 PF05712; MRG
 PF11717; Tudor-knot 

SMART

  

PROSITE

 PS51640; MRG 

PRINTS