CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016780
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Abl interactor 1 
Protein Synonyms/Alias
 Abelson interactor 1; Abi-1; Ablphilin-1; Eps8 SH3 domain-binding protein; Eps8-binding protein; Spectrin SH3 domain-binding protein 1; e3B1 
Gene Name
 Abi1 
Gene Synonyms/Alias
 Ssh3bp1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
154DDVGHGVKWLKAKHGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. 
Sequence Annotation
 DOMAIN 45 107 t-SNARE coiled-coil homology.
 DOMAIN 419 478 SH3.
 REGION 18 79 Required for binding to WASF1.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 213 213 Phosphotyrosine; alternate.
 MOD_RES 213 213 Phosphotyrosine; by ABL1; alternate (By
 MOD_RES 216 216 Phosphoserine (By similarity).
 MOD_RES 222 222 Phosphoserine.
 MOD_RES 225 225 Phosphoserine (By similarity).
 MOD_RES 296 296 Phosphoserine (By similarity).
 MOD_RES 428 428 Phosphotyrosine.
 MOD_RES 480 480 Phosphothreonine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Cell junction; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome; SH3 domain; Synapse; Synaptosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 481 AA 
Protein Sequence
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET KAYTTQSLAS 60
VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR 120
THKIIAPANM ERPVRYIRKP IDYTVLDDVG HGVKWLKAKH GNNQPARTGT LSRTNPPTQK 180
PPSPPVSGRG TLGRNTPYKT LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS 240
GSSGGSGSRE NSGSSSIGIP IAVPTPSPPT AGPAAPGAAP GSQYGTMTRQ ISRHNSTTSS 300
TSSGGYRRTP SVAAQFSAQP HVNGGPLYSQ NSISVAPPPP PMPQLTPQIP LTGFVARVQE 360
NIADSPTPPP PPPPDDIPMF DDSPPPPPPP PVDYEDEEAA VVQYSDPYAD GDPAWAPKNY 420
IEKVVAIYDY TKDKDDELSF KEGAIIYVIK KNDDGWFEGV CNRVTGLFPG NYVESIMHYT 480
D 481 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
 GO:0005622; C:intracellular; ISA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0043005; C:neuron projection; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0030296; F:protein tyrosine kinase activator activity; IDA:MGI.
 GO:0006928; P:cellular component movement; IEA:Compara.
 GO:0072673; P:lamellipodium morphogenesis; IMP:MGI.
 GO:0035855; P:megakaryocyte development; IMP:MGI.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; ISA:MGI.
 GO:0001756; P:somitogenesis; IMP:MGI. 
Interpro
 IPR012849; Abl-interactor_HHR_dom.
 IPR000108; p67phox.
 IPR001452; SH3_domain.
 IPR000727; T_SNARE_dom. 
Pfam
 PF07815; Abi_HHR
 PF00018; SH3_1 
SMART
 SM00326; SH3 
PROSITE
 PS50002; SH3
 PS50192; T_SNARE 
PRINTS
 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.