CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037847
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 
Protein Synonyms/Alias
  
Gene Name
 STT3A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47YHLTKELKDAGAGLLubiquitination[1]
197FVDYLRSKLNPQQFEubiquitination[1, 2, 3]
348LDISRPDKKSKKQQDubiquitination[2]
349DISRPDKKSKKQQDSubiquitination[4]
352RPDKKSKKQQDSTYPubiquitination[1, 2]
429HNTPEDAKVMSWWDYubiquitination[3]
473AMASTEEKAYEIMREubiquitination[1, 2, 3, 4, 5]
518GGSTDTGKHIKENDYubiquitination[1, 2, 3, 4, 5]
521TDTGKHIKENDYYTPubiquitination[1, 2, 3, 4, 5, 6]
549LLNCLMYKMCYYRFGubiquitination[2, 3]
563GQVYTEAKRPPGFDRubiquitination[1, 2, 3, 4, 5, 6]
579RNAEIGNKDFELDVLubiquitination[1, 2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 613 AA 
Protein Sequence
MITSAAIYHV LHFFHITIDI RNVCVFLAPL FSSFTTIVTY HLTKELKDAG AGLLAAAMIA 60
VVPGYISRSV AGSYDNEGIA IFCMLLTYYM WIKAVKTGSI CWAAKCALAY FYMVSSWGGY 120
VFLINLIPLH VLVLMLTGRF SHRIYVAYCT VYCLGTILSM QISFVGFQPV LSSEHMAAFG 180
VFGLCQIHAF VDYLRSKLNP QQFEVLFRSV ISLVGFVLLT VGALLMLTGK ISPWTGRFYS 240
LLDPSYAKNN IPIIASVSEH QPTTWSSYYF DLQLLVFMFP VGLYYCFSNL SDARIFIIMY 300
GVTSMYFSAV MVRLMLVLAP VMCILSGIGV SQVLSTYMKN LDISRPDKKS KKQQDSTYPI 360
KNEVASGMIL VMAFFLITYT FHSTWVTSEA YSSPSIVLSA RGGDGSRIIF DDFREAYYWL 420
RHNTPEDAKV MSWWDYGYQI TAMANRTILV DNNTWNNTHI SRVGQAMAST EEKAYEIMRE 480
LDVSYVLVIF GGLTGYSSDD INKFLWMVRI GGSTDTGKHI KENDYYTPTG EFRVDREGSP 540
VLLNCLMYKM CYYRFGQVYT EAKRPPGFDR VRNAEIGNKD FELDVLEEAY TTEHWLVRIY 600
KVKDLDNRGL SRT 613 
Gene Ontology
 GO:0016020; C:membrane; IEA:Compara.
 GO:0004576; F:oligosaccharyl transferase activity; IEA:InterPro.
 GO:0006486; P:protein glycosylation; IEA:InterPro. 
Interpro
 IPR003674; Oligo_trans_STT3. 
Pfam
 PF02516; STT3 
SMART
  
PROSITE
  
PRINTS