UniProt Accession

 KC1A_DROME; P54367; A4V4D3; Q0KHT2; Q9VYK2 

Genbank Protein ID

 U55848; X94695; AE014298; AE014298; AY069346 

Genbank Nucleotide ID

 AAB16904.1; CAA64358.1; AAF48192.1; AAN09313.1; AAL39491.1 

Protein Name

 Casein kinase I isoform alpha 

Protein Synonyms/Alias

 CKI-alpha; DmCK1 

Gene Name

 CkIalpha 

Gene Synonyms/Alias

 CKI; CG2028 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
19	PEIIVGGKYRVIRKI	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May be required for mechanisms associated with DNA repair during early embryogenesis. 

Sequence Annotation

 DOMAIN 20 288 Protein kinase.
 NP_BIND 26 34 ATP (By similarity).
 ACT_SITE 139 139 Proton acceptor (By similarity).
 BINDING 49 49 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:FlyBase.
 GO:0000902; P:cell morphogenesis; IMP:FlyBase.
 GO:0006281; P:DNA repair; IDA:FlyBase.
 GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase.
 GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:FlyBase.
 GO:0030163; P:protein catabolic process; NAS:FlyBase.
 GO:0030111; P:regulation of Wnt receptor signaling pathway; IMP:FlyBase.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS