CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023338
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin-binding protein anillin 
Protein Synonyms/Alias
 Actin-binding protein 8; ABP8; Protein scraps 
Gene Name
 scra 
Gene Synonyms/Alias
 ani; CG2092 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
83TLEASPAKPLRHYTAacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embryonic viability. 
Sequence Annotation
 DOMAIN 1106 1230 PH.
 REGION 126 371 Interaction with and bundling of F-actin.
 MOD_RES 712 712 Phosphoserine.
 MOD_RES 740 740 Phosphothreonine.
 MOD_RES 744 744 Phosphoserine.
 MOD_RES 754 754 Phosphoserine.
 MOD_RES 831 831 Phosphothreonine.  
Keyword
 Actin-binding; Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Meiosis; Mitosis; Nucleus; Oogenesis; Phosphoprotein; Reference proteome; Spermatogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1239 AA 
Protein Sequence
MDPFTQHMLE KAEQRSRALG ISNASKFPLV ECSVPSSSAT SASGGDAGVL APRSRSPGGQ 60
SAASGGGKVV TLGKATLEAS PAKPLRHYTA VNKENLDMGI EINITTDKPI GVQVEIQEQE 120
VTDDEEQAEG GALNPLLEAE PVNQPLARLR DTSRSRLQRM GALYSNTDDL SSPIHRTEGQ 180
FHVTTGEEED CGNRSSRQPK QRLGKLAALA DTINQWEDDT SHHEVHRLLE APPPKPHLSS 240
RRAEKGPAPL PPKKDEVDEA SRTKQLKWDP KVLSSLEAQG FQRRESSTIK HTYDYAKQEE 300
AAPASKVEDA VLTAKPPVPQ KSTTVSQVAK NFASSAPAPK PAPAPAVSVK SGLVSGRAAL 360
FENKGTGGQS QGLRNQKDPC ELSLKERMKL FETGNNKAML PMAPIGSAPS ITQIRAEEVK 420
QHLAAMHPVT AAAATTVVAA TKPKQENKLR DKVAALVANA QSSAETRIKD IDRQRQEDMQ 480
IISNRFNKQK ELFDNQPSDS SVAAQARPPA PAPSRVVRPM PPPPPPPIAA LSPGLASSKR 540
RSPGDAPTTD EDSKRARKSH SDRLYPALSD LDSSGDNCCA AETASATDDS HQQDEEETES 600
CMDESDDQSQ TEDSSAGMCN GSLGREIMSA VQRNEVEMQQ QQTGKKTVRY ADQDMYYDDS 660
SLNSSQVSAG IDDYLDEALV EDYGSTQDDQ SDSGDEQNAS RLSLGSKGTT ASNSFSFRKN 720
PASICTPIEE HHEMEMDLQT PLLSGAQPVK SELSVNQDND NLVTLVHTVS FYRRQQSANS 780
SNSTPVRKIC REQQVMRSAL AGDCHAKHRL EYDSPQQSDY VAAATDIADQ TDEDDEEMQN 840
AREVNDASQA QDKIKKLLSE VCKQQQVIGQ ASQALNLCAA TVEFSGSTES VEGERYLLLA 900
THRRQACLDE VQRLRVENSI RPVGAPKEKG LLTVKDITIP LRQEYVRKMA SNNINGHHLV 960
CLLKYNEHVL ATKTVPTMPG LLSVKFPDVL QLNNVYADFR ITLEIYGMLA QRDQLPHELK 1020
YHINLNKKGG IKTPKKKGGE NRLVMPPVQS PAGPHVVRTP QLVQYGFAIF SLREIQRTTW 1080
TLTQVLGVSP LEGVVHMKVN CELSVSVEYK GFLTMFEDIS GFGAWHRRWC YLNGSVINYW 1140
KYPDDEKRKT PMGSIDLNSC TSQKVTTAPR DICARLNTML LECERPALET DQESLIIVPN 1200
GRTTTVRHLL SADTKEEREE WCAYLNKALT LLRAWGTTH 1239 
Gene Ontology
 GO:0005826; C:actomyosin contractile ring; IDA:UniProtKB.
 GO:0035323; C:male germline ring canal; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003779; F:actin binding; IDA:FlyBase.
 GO:0008017; F:microtubule binding; IDA:FlyBase.
 GO:0017022; F:myosin binding; IDA:UniProtKB.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0051297; P:centrosome organization; IMP:FlyBase.
 GO:0000915; P:cytokinesis, actomyosin contractile ring assembly; IMP:UniProtKB.
 GO:0032189; P:maintenance of actomyosin contractile ring localization; IMP:FlyBase.
 GO:0030726; P:male germline ring canal formation; IMP:UniProtKB.
 GO:0007112; P:male meiosis cytokinesis; IMP:FlyBase.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
 GO:0007009; P:plasma membrane organization; IMP:UniProtKB.
 GO:0007279; P:pole cell formation; IMP:UniProtKB.
 GO:0051533; P:positive regulation of NFAT protein import into nucleus; IMP:FlyBase.
 GO:0008104; P:protein localization; IMP:UniProtKB.
 GO:0045035; P:sensory organ precursor cell division; IMP:FlyBase.
 GO:0031106; P:septin ring organization; IMP:FlyBase. 
Interpro
 IPR012966; DUF1709.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF08174; Anillin
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS50003; PH_DOMAIN 
PRINTS