UniProt Accession

 B4DVG8_HUMAN; B4DVG8 

Genbank Protein ID

 AC009087; AK301074 

Genbank Nucleotide ID

 BAG62680.1 

Protein Name

 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 

Protein Synonyms/Alias

 Uncharacterized protein; cDNA FLJ51112, highly similar to Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.1.-) 

Gene Name

 DHX38 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
105	DQAKIFQKAPDGVRK	ubiquitination	[1]
141	DSGYCKLKVFNPRIG	ubiquitination	[2, 3]
187	LYTQSAYKNELLTTT	ubiquitination	[2, 3]
361	REVRAQLKDIMVQQR	ubiquitination	[2]
478	QENRRRAKEEASAME	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 539 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 

Interpro

 IPR011709; DUF1605.
 IPR007502; Helicase-assoc_dom.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase. 

Pfam

 PF04408; HA2
 PF00271; Helicase_C
 PF07717; OB_NTP_bind 

SMART

 SM00847; HA2
 SM00490; HELICc 

PROSITE

 PS51194; HELICASE_CTER 

PRINTS