CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015234
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein tyrosine phosphatase type IVA 2 
Protein Synonyms/Alias
 Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2 
Gene Name
 Ptp4a2 
Gene Synonyms/Alias
 Prl2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
29PTNATLNKFTEELKKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity). 
Sequence Annotation
 DOMAIN 79 145 Tyrosine-protein phosphatase.
 REGION 102 107 Phosphate binding (By similarity).
 ACT_SITE 69 69 Proton donor (By similarity).
 ACT_SITE 101 101 Phosphocysteine intermediate (By
 BINDING 107 107 Substrate (By similarity).
 MOD_RES 164 164 Cysteine methyl ester (By similarity).
 LIPID 164 164 S-farnesyl cysteine (By similarity).
 DISULFID 46 101 By similarity.  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Endosome; Hydrolase; Lipoprotein; Membrane; Methylation; Prenylation; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 167 AA 
Protein Sequence
MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY DKAPVEKEGI 60
HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH CVAGLGRAPV LVALALIECG 120
MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR PKMRLRFRDT NGHCCVQ 167 
Gene Ontology
 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR000387; Tyr/Dual-sp_Pase.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF00102; Y_phosphatase 
SMART
  
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS