| Tag | Content |
|---|
| CPLM ID | CPLM-010895 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial import inner membrane translocase subunit TIM44 |
Protein Synonyms/Alias | Inner membrane import site protein 45; ISP45; Membrane import machinery protein MIM44; Mitochondrial protein import protein 1 |
Gene Name | TIM44 |
Gene Synonyms/Alias | ISP45; MIM44; MPI1; YIL022W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 278 | SRVYSQFKLMDPTFS | acetylation | [1] | | 333 | AAQQKIFKEQDVYAD | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co- chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source. |
Sequence Annotation | NP_BIND 101 108 ATP (Potential). |
Keyword | 3D-structure; ATP-binding; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Protein transport; Reference proteome; Transit peptide; Translocation; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 431 AA |
Protein Sequence | MHRSTFIRTS GTSSRTLTAR YRSQYTGLLV ARVLFSTSTT RAQGGNPRSP LQIFRDTFKK 60
EWEKSQELQE NIKTLQDASG KLGESEAYKK AREAYLKAQR GSTIVGKTLK KTGETMEHIA 120
TKAWESELGK NTRKAAAATA KKLDESFEPV RQTKIYKEVS EVIDDGESSR YGGFITKEQR 180
RLKRERDLAS GKRHRAVKSN EDAGTAVVAT NIESKESFGK KVEDFKEKTV VGRSIQSLKN 240
KLWDESENPL IVVMRKITNK VGGFFAETES SRVYSQFKLM DPTFSNESFT RHLREYIVPE 300
ILEAYVKGDV KVLKKWFSEA PFNVYAAQQK IFKEQDVYAD GRILDIRGVE IVSAKLLAPQ 360
DIPVLVVGCR AQEINLYRKK KTGEIAAGDE ANILMSSYAM VFTRDPEQID DDETEGWKIL 420
EFVRGGSRQF T 431 |
Gene Ontology | GO:0016021; C:integral to membrane; ISM:SGD. GO:0001405; C:presequence translocase-associated import motor; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0051087; F:chaperone binding; IMP:SGD. GO:0015450; F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro. GO:0030674; F:protein binding, bridging; IMP:SGD. GO:0030150; P:protein import into mitochondrial matrix; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |