| Tag | Content |
|---|
| CPLM ID | CPLM-017721 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase Praja-1 |
Protein Synonyms/Alias | Praja1; RING finger protein 70 |
Gene Name | PJA1 |
Gene Synonyms/Alias | RNF70 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 66 | SAPSQTTKRSRSPFS | ubiquitination | [1] |
|
Reference | [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI. J Proteome Res. 2012 Feb 3;11(2):796-807. [ PMID: 22053931] |
Functional Description | Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. |
Sequence Annotation | ZN_FING 595 636 RING-type.
MOD_RES 277 277 Phosphothreonine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Ligase; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 643 AA |
Protein Sequence | MGQESSKPVW PNPTGGYQSN TGRRYGRRHA YVSFRPPTSQ RERIASQRKT NSEVPMHRSA 60
PSQTTKRSRS PFSTTRRSWD DSESSGTNLN IDNEDYSSTS RWRDTANDNE GHSDGLARRG 120
RGESSSGYPE PKYPEDKREA RSDQVKPEKV PRRRRTMADP DFWTHSDDYY KYCDEDSDSD 180
KEWIAALRRK YRSREQTLSS SGESWETLPG KEEREPPQAK VSASTGTSPG PGASASAGAG 240
AGASAGSNGS NYLEEVREPS LQEEQASLEE GEIPWLQYHE NDSSSEGDND SGHELMQPGV 300
FMLDGNNNLE DDSSVSEDLE VDWSLFDGFA DGLGVAEAIS YVDPQFLTYM ALEERLAQAM 360
ETALAHLESL AVDVEVANPP ASKESIDALP EILVTEDHGA VGQEMCCPIC CSEYVKGEVA 420
TELPCHHYFH KPCVSIWLQK SGTCPVCRCM FPPPL 455 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |