UniProt Accession

 ARLY_HUMAN; P04424; E7EMI0; E9PE48; Q6LDS5; Q96HS2 

Genbank Protein ID

 Y00753; M14218; J03058; M57638; AF376770; AC068533; BC008195; BC033146; M21007; M21006 

Genbank Nucleotide ID

 CAA68722.1; AAA51786.1; AAA51787.1; AAA51788.1; AAL57276.1; AAH08195.1; AAH33146.1; AAA35566.1; AAA35566.1 

Protein Name

 Argininosuccinate lyase 

Protein Synonyms/Alias

 ASAL; Arginosuccinase 

Gene Name

 ASL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MASESGKLWGGRFV	ubiquitination	[1]
23	AVDPIMEKFNASIAY	ubiquitination	[2]
43	EVDVQGSKAYSRGLE	ubiquitination	[2]
51	AYSRGLEKAGLLTKA	ubiquitination	[1, 2]
57	EKAGLLTKAEMDQIL	ubiquitination	[2]
69	QILHGLDKVAEEWAQ	acetylation	[3]
80	EWAQGTFKLNSNDED	ubiquitination	[2]
97	TANERRLKELIGATA	ubiquitination	[2]
106	LIGATAGKLHTGRSR	ubiquitination	[2]
287	GSSLMPQKKNPDSLE	ubiquitination	[2]
288	SSLMPQKKNPDSLEL	acetylation	[3]
288	SSLMPQKKNPDSLEL	ubiquitination	[2]
323	GLPSTYNKDLQEDKE	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 MOD_RES 69 69 N6-acetyllysine.
 MOD_RES 288 288 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Disease mutation; Lyase; Polymorphism; Reference proteome; Urea cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 464 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004056; F:argininosuccinate lyase activity; EXP:Reactome.
 GO:0019676; P:ammonia assimilation cycle; IEA:Compara.
 GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
 GO:0006527; P:arginine catabolic process; TAS:ProtInc.
 GO:0006475; P:internal protein amino acid acetylation; IDA:UniProtKB.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0000050; P:urea cycle; TAS:Reactome. 

Interpro

 IPR009049; Argininosuccinate_lyase.
 IPR003031; D_crystallin.
 IPR024083; Fumarase/histidase_N.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like. 

Pfam

 PF00206; Lyase_1 

SMART

  

PROSITE

 PS00163; FUMARATE_LYASES 

PRINTS

 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.