UniProt Accession

 KAD1_MOUSE; Q9R0Y5; A2AK80; Q542C5; Q9R0Y4 

Genbank Protein ID

 AJ010108; AJ010109; DQ486026; AK046613; AK089270; AL772271; AL772271; AL772271; BC014802; BC054366 

Genbank Nucleotide ID

 CAB52407.1; CAB52408.1; ABF46940.1; BAC32808.1; BAC40822.1; CAM16612.1; CAM16613.1; CAM16614.1; AAH14802.1; AAH54366.1 

Protein Name

 Adenylate kinase isoenzyme 1 

Protein Synonyms/Alias

 AK 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase 

Gene Name

 Ak1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
37	VGGPGSGKGTQCEKI	ubiquitination	[1]
47	QCEKIVQKYGYTHLS	ubiquitination	[1]
72	SGSERGKKLSAIMEK	ubiquitination	[1]
99	LRDAMLAKVDSSNGF	ubiquitination	[1]
116	DGYPREVKQGEEFEQ	ubiquitination	[1]
163	DDNEETIKKRLETYY	ubiquitination	[1]
164	DNEETIKKRLETYYN	ubiquitination	[1]
182	PVISFYDKRGIVRKV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). May provide a mechanism to buffer the adenylate energy charge for sperm motility. 

Sequence Annotation

 NP_BIND 18 23 ATP (By similarity).
 NP_BIND 65 67 AMP (By similarity).
 NP_BIND 94 97 AMP (By similarity).
 REGION 38 67 NMPbind (By similarity).
 REGION 131 141 LID (By similarity).
 BINDING 39 39 AMP (By similarity).
 BINDING 44 44 AMP (By similarity).
 BINDING 101 101 AMP (By similarity).
 BINDING 132 132 ATP (By similarity).
 BINDING 138 138 AMP (By similarity).
 BINDING 149 149 AMP (By similarity).
 BINDING 177 177 ATP; via carbonyl oxygen (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0001520; C:outer dense fiber; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0036126; C:sperm flagellum; IDA:MGI.
 GO:0004017; F:adenylate kinase activity; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046034; P:ATP metabolic process; IEA:InterPro.
 GO:0007050; P:cell cycle arrest; IDA:MGI. 

Interpro

 IPR000850; Adenylate_kin.
 IPR006267; Adenylate_kin1.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.