CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016076
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein LYRIC 
Protein Synonyms/Alias
 3D3/LYRIC; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein 
Gene Name
 Mtdh 
Gene Synonyms/Alias
 Lyric 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
106PDDLAQLKNLRSEEQubiquitination[1]
184NSSRHDGKEVDEGAWacetylation[2]
184NSSRHDGKEVDEGAWubiquitination[1]
247PVGSKKNKGDSHLNVubiquitination[1]
288NGGGWSEKSVKLSSQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity). 
Sequence Annotation
 REGION 1 71 Activation of NF-kappa-B (By similarity).
 REGION 72 168 Interaction with BCCIP (By similarity).
 REGION 100 204 Interaction with RELA (By similarity).
 REGION 378 440 Lung-homing for mammary tumors.
 MOD_RES 294 294 Phosphoserine.
 MOD_RES 297 297 Phosphoserine.
 MOD_RES 303 303 Phosphoserine (By similarity).
 MOD_RES 308 308 Phosphoserine (By similarity).
 MOD_RES 341 341 Phosphoserine (By similarity).
 MOD_RES 366 366 Phosphoserine (By similarity).
 MOD_RES 412 412 Phosphoserine (By similarity).
 MOD_RES 423 423 Phosphoserine.
 MOD_RES 565 565 Phosphoserine (By similarity).  
Keyword
 Cell junction; Complete proteome; Cytoplasm; Endoplasmic reticulum; Membrane; Nucleus; Phosphoprotein; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 579 AA 
Protein Sequence
MAARSWQDEL AQQAEEGSAR LRELLSVGLG FLRTELGLDL GLEPKRYPGW VILVGTGALG 60
LLLLFLLGYG WAAACAGARK KRRSPPRKRE EAAPPTPAPD DLAQLKNLRS EEQKKKNRKK 120
LPEKPKPNGR TVEVPEDEVV RNPRSITAKQ APETDKKNEK SKKNKKKSKS DAKAVQNSSR 180
HDGKEVDEGA WETKISHREK RQQRKRDKVL TDSGSLDSTI PGIENIITVT TEQLTTASFP 240
VGSKKNKGDS HLNVQVSNFK SGKGDSTLQV SSRLNENLTV NGGGWSEKSV KLSSQLSEEK 300
WNSVPPASAG KRKTEPSAWT QDTGDTNANG KDWGRNWSDR SIFSGIGSTA EPVSQSTTSD 360
YQWDVSRNQP YIDDEWSGLN GLSSADPSSD WNAPAEEWGN WVDEDRASLL KSQEPISNDQ 420
KVSDDDKEKG EGALPTGKSK KKKKKKKKQG EDNSHTQDTE DLEKDTREEL PVNTSKARPK 480
QEKACSLKTM STSDPAEVLI KNSQPVKTLP PAISAEPSIT LSKGDSDNSS SQVPPMLQDT 540
DKPKSNAKQN SVPPSQTKSE TNWESPKQIK KKKKARRET 579 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0046581; C:intercellular canaliculus; IEA:Compara.
 GO:0016604; C:nuclear body; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
 GO:0051059; F:NF-kappaB binding; ISS:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0010508; P:positive regulation of autophagy; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0070830; P:tight junction assembly; IEA:Compara. 
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