| Tag | Content |
|---|
| CPLM ID | CPLM-016437 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Atlastin-1 |
Protein Synonyms/Alias | Spastic paraplegia 3A homolog |
Gene Name | Atl1 |
Gene Synonyms/Alias | Spg3a |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 364 | LAAVATAKDTYNKKM | ubiquitination | [1] | | 395 | QSKHLQLKEESVKLF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development (By similarity). |
Sequence Annotation | NP_BIND 74 81 GTP (Potential).
NP_BIND 146 150 GTP (Potential).
REGION 448 558 Sufficient for membrane association (By
MOD_RES 10 10 Phosphoserine.
MOD_RES 18 18 Phosphoserine.
MOD_RES 22 22 Phosphoserine.
MOD_RES 23 23 Phosphoserine. |
Keyword | Cell projection; Coiled coil; Complete proteome; Endoplasmic reticulum; Golgi apparatus; GTP-binding; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 558 AA |
Protein Sequence | MAKSRRDRNS WGGFSEKSSD WSSEEEEPVR KAGPVQVLIV KDDHSFELDE AALNRILLSQ 60
AVRDKEVVAV SVAGAFRKGK SFLMDFMLRY MYNQESVDWV GDYNEPLTGF SWRGGSERET 120
TGIQIWSEVF LINKLDGKKV AVLLMDTQGT FDSQSTLRDS ATVFALSTMI SSIQVYNLSQ 180
NVQEDDLQHL QLFTEYGRLA MEETFLKPFQ SLIFLVRDWS FPYEFSYGAD GGAKFLEKRL 240
KVSGNQHEEL QNVRKHIHSC FTNISCFLLP HPGLKVATNP NFDGKLKEID DEFIKNLKIL 300
IPWLLSPERL DIKEINGNKI TCRGLLEYFK AYIKIYQGEE LPHPKSMLQA TAEANNLAAV 360
ATAKDTYNKK MEEVCGGDKP FLAPNDLQSK HLQLKEESVK LFRGVKKMGG EEFSRRYLQQ 420
LESEIDELYI QYIKHNDSKN IFHAARTPAT LFVVIFITYV IAGVTGFIGL DIIASLCNMI 480
MGLTLITLCT WAYIRYSGEY RELGAVIDQV AAALWDQGST NEALYKLYSA AATHRHLCHQ 540
AFPAPKSEPT QQPEKKKI 558 |
Gene Ontology | GO:0030424; C:axon; IEA:UniProtKB-SubCell. GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB. GO:0000137; C:Golgi cis cisterna; ISS:UniProtKB. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; ISS:UniProtKB. GO:0005525; F:GTP binding; ISS:UniProtKB. GO:0003924; F:GTPase activity; ISS:UniProtKB. GO:0042802; F:identical protein binding; ISS:UniProtKB. GO:0007409; P:axonogenesis; ISS:UniProtKB. GO:0007029; P:endoplasmic reticulum organization; ISS:UniProtKB. GO:0051260; P:protein homooligomerization; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |