CPLM-002246

Genbank Nucleotide ID

Glucose-6-phosphate 1-dehydrogenase

Protein Synonyms/Alias

Rattus norvegicus (Rat)

Position	Peptide	Type	References
119	YDDPASYKHLNSHMN	acetylation	[1]
171	WNRIIVEKPFGRDLQ	acetylation	[1]
403	PNEAVYTKMMTKKPG	acetylation	[1]
408	YTKMMTKKPGMFFNP	acetylation	[1]
432	GNRYKNVKLPDAYER	acetylation	[1]
497	TEADELMKRVGFQYE	acetylation	[1]

[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]

Functional Description

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).

NP_BIND 38 45 NADP 1 (By similarity).
NP_BIND 401 403 NADP 2 (By similarity).
NP_BIND 421 423 NADP 2 (By similarity).
REGION 201 205 Substrate binding (By similarity).
ACT_SITE 263 263 Proton acceptor (By similarity).
BINDING 72 72 NADP 1 (By similarity).
BINDING 147 147 NADP 1 (By similarity).
BINDING 171 171 NADP 1; via carbonyl oxygen (By
BINDING 171 171 Substrate (By similarity).
BINDING 239 239 Substrate (By similarity).
BINDING 258 258 Substrate (By similarity).
BINDING 357 357 NADP 2 (By similarity).
BINDING 360 360 Substrate (By similarity).
BINDING 365 365 Substrate (By similarity).
BINDING 366 366 NADP 2 (By similarity).
BINDING 370 370 NADP 2 (By similarity).
BINDING 393 393 NADP 2 (By similarity).
BINDING 395 395 Substrate (By similarity).
BINDING 487 487 NADP 2 (By similarity).
BINDING 503 503 NADP 2 (By similarity).
BINDING 509 509 NADP 2 (By similarity).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 89 89 N6-acetyllysine (By similarity).
MOD_RES 171 171 N6-acetyllysine (By similarity).
MOD_RES 403 403 N6-acetyllysine (By similarity).
MOD_RES 432 432 N6-acetyllysine (By similarity).
MOD_RES 497 497 N6-acetyllysine (By similarity).

Acetylation; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Glucose metabolism; NADP; Oxidoreductase; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005813; C:centrosome; IEA:Compara.
GO:0005829; C:cytosol; IDA:RGD.
GO:0009898; C:internal side of plasma membrane; IEA:Compara.
GO:0005634; C:nucleus; IDA:RGD.
GO:0005536; F:glucose binding; IDA:RGD.
GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IDA:RGD.
GO:0050661; F:NADP binding; IDA:RGD.
GO:0034599; P:cellular response to oxidative stress; IEA:Compara.
GO:0006695; P:cholesterol biosynthetic process; IEA:Compara.
GO:0001816; P:cytokine production; IEA:Compara.
GO:0043249; P:erythrocyte maturation; IEA:Compara.
GO:0051156; P:glucose 6-phosphate metabolic process; IDA:RGD.
GO:0006749; P:glutathione metabolic process; IEA:Compara.
GO:0010734; P:negative regulation of protein glutathionylation; IEA:Compara.
GO:0019322; P:pentose biosynthetic process; IEA:Compara.
GO:0009051; P:pentose-phosphate shunt, oxidative branch; IMP:RGD.
GO:0043523; P:regulation of neuron apoptotic process; IDA:RGD.
GO:0045471; P:response to ethanol; IDA:RGD.
GO:0032094; P:response to food; IEP:RGD.
GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO:0046390; P:ribose phosphate biosynthetic process; IEA:Compara.

IPR001282; G6P_DH.
IPR019796; G6P_DH_AS.
IPR022675; G6P_DH_C.
IPR022674; G6P_DH_NAD-bd.
IPR016040; NAD(P)-bd_dom.

PF02781; G6PD_C
PF00479; G6PD_N

PS00069; G6P_DEHYDROGENASE

PR00079; G6PDHDRGNASE.