| Tag | Content |
|---|
| CPLM ID | CPLM-011914 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | EGF-containing fibulin-like extracellular matrix protein 1 |
Protein Synonyms/Alias | Extracellular protein S1-5; Fibrillin-like protein; Fibulin-3; FIBL-3 |
Gene Name | EFEMP1 |
Gene Synonyms/Alias | FBLN3; FBNL |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 207 | QCPPGYQKRGEQCVD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. |
Sequence Annotation | DOMAIN 26 71 EGF-like 1; atypical.
DOMAIN 173 213 EGF-like 2; calcium-binding (Potential).
DOMAIN 214 253 EGF-like 3; calcium-binding (Potential).
DOMAIN 254 293 EGF-like 4; calcium-binding (Potential).
DOMAIN 294 333 EGF-like 5; calcium-binding (Potential).
DOMAIN 334 378 EGF-like 6; calcium-binding (Potential).
REGION 259 493 Mediates interaction with TIMP3.
CARBOHYD 249 249 N-linked (GlcNAc...) (Potential).
DISULFID 177 190 By similarity.
DISULFID 184 199 By similarity.
DISULFID 201 212 By similarity.
DISULFID 218 228 By similarity.
DISULFID 224 237 By similarity.
DISULFID 239 252 By similarity.
DISULFID 258 268 By similarity.
DISULFID 264 277 By similarity.
DISULFID 279 292 By similarity.
DISULFID 298 309 By similarity.
DISULFID 305 318 By similarity.
DISULFID 320 332 By similarity.
DISULFID 338 350 By similarity.
DISULFID 344 359 By similarity.
DISULFID 365 377 By similarity. |
Keyword | Alternative splicing; Calcium; Complete proteome; Disease mutation; Disulfide bond; EGF-like domain; Extracellular matrix; Glycoprotein; Growth factor; Polymorphism; Reference proteome; Repeat; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 493 AA |
Protein Sequence | MLKALFLTML TLALVKSQDT EETITYTQCT DGYEWDPVRQ QCKDIDECDI VPDACKGGMK 60
CVNHYGGYLC LPKTAQIIVN NEQPQQETQP AEGTSGATTG VVAASSMATS GVLPGGGFVA 120
SAAAVAGPEM QTGRNNFVIR RNPADPQRIP SNPSHRIQCA AGYEQSEHNV CQDIDECTAG 180
THNCRADQVC INLRGSFACQ CPPGYQKRGE QCVDIDECTI PPYCHQRCVN TPGSFYCQCS 240
PGFQLAANNY TCVDINECDA SNQCAQQCYN ILGSFICQCN QGYELSSDRL NCEDIDECRT 300
SSYLCQYQCV NEPGKFSCMC PQGYQVVRSR TCQDINECET TNECREDEMC WNYHGGFRCY 360
PRNPCQDPYI LTPENRCVCP VSNAMCRELP QSIVYKYMSI RSDRSVPSDI FQIQATTIYA 420
NTINTFRIKS GNENGEFYLR QTSPVSAMLV LVKSLSGPRE HIVDLEMLTV SSIGTFRTSS 480
VLRLTIIVGP FSF 493 |
Gene Ontology | GO:0005615; C:extracellular space; IDA:UniProtKB. GO:0005578; C:proteinaceous extracellular matrix; TAS:ProtInc. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0005154; F:epidermal growth factor receptor binding; IDA:UniProtKB. GO:0005006; F:epidermal growth factor-activated receptor activity; IDA:UniProtKB. GO:0030198; P:extracellular matrix organization; TAS:Reactome. GO:0032331; P:negative regulation of chondrocyte differentiation; IDA:UniProtKB. GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0007601; P:visual perception; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |