CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002730
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fibroblast growth factor 2 
Protein Synonyms/Alias
 FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2 
Gene Name
 FGF2 
Gene Synonyms/Alias
 FGFB 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
168DPKRLYCKNGGFFLRacetylation[1]
261TSWYVALKRTGQYKLacetylation[1]
277SKTGPGQKAILFLPMacetylation[1]
Reference
 [1] epsilon-N-acetylation in the production of recombinant human basic fibroblast growth factor mutein.
 Suenaga M, Ohmae H, Tsuji S, Tanaka Y, Koyama N, Nishimura O.
 Prep Biochem Biotechnol. 1996 Aug-Nov;26(3-4):259-70. [PMID: 8958573] 
Functional Description
 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. 
Sequence Annotation
 REGION 261 277 Heparin-binding (By similarity).
 MOTIF 179 181 Cell attachment site; atypical
 MOTIF 221 223 Cell attachment site; atypical
 BINDING 169 169 Heparin (By similarity).
 MOD_RES 108 108 Omega-N-methylarginine; alternate (By
 MOD_RES 108 108 Symmetric dimethylarginine; alternate (By
 MOD_RES 110 110 Omega-N-methylarginine; alternate (By
 MOD_RES 110 110 Symmetric dimethylarginine; alternate (By
 MOD_RES 112 112 Omega-N-methylarginine; alternate (By
 MOD_RES 112 112 Symmetric dimethylarginine; alternate (By
 MOD_RES 215 215 Phosphotyrosine; by TEC.  
Keyword
 3D-structure; Alternative initiation; Angiogenesis; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Growth factor; Heparin-binding; Methylation; Mitogen; Nucleus; Phosphoprotein; Reference proteome; Secreted. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 288 AA 
Protein Sequence
MVGVGGGDVE DVTPRPGGCQ ISGRGARGCN GIPGAAAWEA ALPRRRPRRH PSVNPRSRAA 60
GSPRTRGRRT EERPSGSRLG DRGRGRALPG GRLGGRGRGR APERVGGRGR GRGTAAPRAA 120
PAARGSRPGP AGTMAAGSIT TLPALPEDGG SGAFPPGHFK DPKRLYCKNG GFFLRIHPDG 180
RVDGVREKSD PHIKLQLQAE ERGVVSIKGV CANRYLAMKE DGRLLASKCV TDECFFFERL 240
ESNNYNTYRS RKYTSWYVAL KRTGQYKLGS KTGPGQKAIL FLPMSAKS 288 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0042056; F:chemoattractant activity; IDA:BHF-UCL.
 GO:0005125; F:cytokine activity; IDA:BHF-UCL.
 GO:0008083; F:growth factor activity; IDA:BHF-UCL.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:UniProtKB.
 GO:0000187; P:activation of MAPK activity; TAS:ProtInc.
 GO:0000186; P:activation of MAPKK activity; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
 GO:0006700; P:C21-steroid hormone biosynthetic process; IEA:Compara.
 GO:0002042; P:cell migration involved in sprouting angiogenesis; IDA:BHF-UCL.
 GO:0060591; P:chondroblast differentiation; IDA:UniProtKB.
 GO:0060128; P:corticotropin hormone secreting cell differentiation; IEA:Compara.
 GO:0048598; P:embryonic morphogenesis; TAS:DFLAT.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; IDA:UniProtKB.
 GO:0010001; P:glial cell differentiation; IEA:Compara.
 GO:0030214; P:hyaluronan catabolic process; IDA:UniProtKB.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0032958; P:inositol phosphate biosynthetic process; IDA:DFLAT.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0060644; P:mammary gland epithelial cell differentiation; IEA:Compara.
 GO:0000189; P:MAPK import into nucleus; IEA:Compara.
 GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
 GO:0060548; P:negative regulation of cell death; IDA:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0010764; P:negative regulation of fibroblast migration; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0061045; P:negative regulation of wound healing; IDA:UniProtKB.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0001759; P:organ induction; IEA:Compara.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:DFLAT.
 GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
 GO:0045766; P:positive regulation of angiogenesis; IDA:DFLAT.
 GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IDA:BHF-UCL.
 GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
 GO:0042660; P:positive regulation of cell fate specification; IDA:MGI.
 GO:0021940; P:positive regulation of cerebellar granule cell precursor proliferation; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IMP:BHF-UCL.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IDA:DFLAT.
 GO:0010863; P:positive regulation of phospholipase C activity; IDA:DFLAT.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0007265; P:Ras protein signal transduction; TAS:ProtInc.
 GO:0051726; P:regulation of cell cycle; IEA:Compara.
 GO:0046668; P:regulation of retinal cell programmed cell death; IEA:Compara.
 GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:DFLAT.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0048864; P:stem cell development; IEA:Compara.
 GO:0021762; P:substantia nigra development; IEA:Compara.
 GO:0060129; P:thyroid-stimulating hormone-secreting cell differentiation; IEA:Compara.
 GO:0042060; P:wound healing; TAS:DFLAT. 
Interpro
 IPR008996; Cytokine_IL1-like.
 IPR002209; GF_heparin-bd.
 IPR002348; IL1_HBGF. 
Pfam
 PF00167; FGF 
SMART
 SM00442; FGF 
PROSITE
 PS00247; HBGF_FGF 
PRINTS
 PR00263; HBGFFGF.
 PR00262; IL1HBGF.