UniProt Accession

 GADE_ECOLI; P63204; P29688; Q2M7H4 

Genbank Protein ID

 U00039; U00096; AP009048; D11389 

Genbank Nucleotide ID

 AAB18488.1; AAC76537.1; BAE77782.1 

Protein Name

 Transcriptional regulator GadE 

Protein Synonyms/Alias

  

Gene Name

 gadE 

Gene Synonyms/Alias

 yhiE; yhiT; b3512; JW3480 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
63	EAIKFLEKLDAERII	acetylation	[1]
79	LAPYHISKLKAKAPI	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci. 

Sequence Annotation

 DOMAIN 109 174 HTH luxR-type.
 DNA_BIND 133 152 H-T-H motif (By similarity).  

Keyword

 Activator; Complete proteome; DNA-binding; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003677; F:DNA binding; IDA:EcoCyc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016032; Sig_transdc_resp-reg_C-effctor.
 IPR000792; Tscrpt_reg_LuxR_C.
 IPR011991; WHTH_DNA-bd_dom.
 IPR013022; Xyl_isomerase-like_TIM-brl. 

Pfam

 PF00196; GerE 

SMART

  

PROSITE

 PS00622; HTH_LUXR_1
 PS50043; HTH_LUXR_2 

PRINTS