| Tag | Content |
|---|
| CPLM ID | CPLM-001345 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DBIRD complex subunit ZNF326 |
Protein Synonyms/Alias | Zinc finger protein 326; Zinc finger protein interacting with mRNPs; Zinc finger protein-associated with nuclear matrix of 75 kDa |
Gene Name | Znf326 |
Gene Synonyms/Alias | Zan75; Zfp326; Zird |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 459 | ILNNPIVKARYERFV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity). May also play a role in neuronal differentiation. Able to bind DNA and activate expression in vitro. |
Sequence Annotation | ZN_FING 312 336 C2H2 AKAP95-type 1.
ZN_FING 405 430 C2H2 AKAP95-type 2.
REGION 1 124 Mediates transcriptional activation.
MOTIF 238 260 Bipartite nuclear localization signal.
MOD_RES 106 106 Phosphoserine (By similarity).
MOD_RES 121 121 Phosphoserine (By similarity).
MOD_RES 137 137 Phosphoserine (By similarity).
MOD_RES 189 189 Phosphoserine.
MOD_RES 190 190 Phosphotyrosine.
MOD_RES 247 247 N6-acetyllysine (By similarity).
MOD_RES 270 270 Phosphoserine (By similarity). |
Keyword | Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 580 AA |
Protein Sequence | MDFEDDYVHS TCRGAYQDFN GMDRDYGPGS YGGLDRDYGH GSYGGQRSMD SYLNQSYGMD 60
NHSGGGGGSR FGPYESYDSR SSLGGRDLYR SGYGFNEPEQ TRFGGSYGGR FESSYRNSLD 120
SFGGRNQGGS SWEAPYSRSK LRPGFMEDRG RENYSSYSSF SSPHMKPAPV GSRGRGTPAY 180
PESTFGSRSY DAFGGPSTGR GRGRGHMGDF GSFHRPGIIV DYQNKPANVT IATARGIKRK 240
MMQIFIKPGG AFIKKPKLAK PMDKMNLSKS PTKTDPKNEE EEKRRIEARR EKQRRRREKN 300
SEKYGDGYRM AFTCSFCKFR TFEEKDIELH LESSSHQETL DHIQKQTKFD KVVMEFLHEC 360
MVNKFKKASI RKQQTLNHPE AYKIIEKDIM EGVTADDHMM KVETVHCSAC SVYIPALHSS 420
VQLHLKSPDH SKGKQAYKEQ IKRESVLTAT SILNNPIVKA RYERFVKGEN PFEIQDHPQD 480
QQIEGDEEDE EKIDEPIEEE EEEEEEEEEE GEEAGSVEEE GDVEGEEGTA EAAAAGEADA 540
VGEAEGAGEA EEAEEEEEEE GTQEFAAQAC ATEQCEHRQM 580 |
Gene Ontology | GO:0044609; C:DBIRD complex; ISS:UniProtKB. GO:0016363; C:nuclear matrix; IDA:MGI. GO:0005681; C:spliceosomal complex; IEA:Compara. GO:0003677; F:DNA binding; IDA:MGI. GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IDA:MGI. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI. GO:0032784; P:regulation of DNA-dependent transcription, elongation; ISS:UniProtKB. GO:0008380; P:RNA splicing; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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