UniProt Accession

 CXG1_HUMAN; P36383; B3KW68; Q4VAY0 

Genbank Protein ID

 U03493; AK124339; AC005180; BC096213; BC096214; BC096215; BC096216 

Genbank Nucleotide ID

 AAA60458.1; BAG54030.1; AAH96213.1; AAH96214.1; AAH96215.1; AAH96216.1 

Protein Name

 Gap junction gamma-1 protein 

Protein Synonyms/Alias

 Connexin-45; Cx45; Gap junction alpha-7 protein 

Gene Name

 GJC1 

Gene Synonyms/Alias

 GJA7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
115	DKKAARSKPYAMRWK	methylation	[1]
150	EMELESDKENKEQSQ	ubiquitination	[2, 3]
265	IRDSLNSKRRELEDP	ubiquitination	[2]
295	PGYNIAVKPDQIQYT	ubiquitination	[2, 3]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 

Sequence Annotation

  

Keyword

 3D-structure; Cell junction; Cell membrane; Complete proteome; Gap junction; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 396 AA 

Protein Sequence

Gene Ontology

 GO:0005922; C:connexon complex; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005921; C:gap junction; TAS:ProtInc.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0014704; C:intercalated disc; TAS:BHF-UCL.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005243; F:gap junction channel activity; IEA:Compara.
 GO:0005216; F:ion channel activity; IEA:Compara.
 GO:0048738; P:cardiac muscle tissue development; IEA:Compara.
 GO:0048468; P:cell development; IEA:Compara.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0016264; P:gap junction assembly; TAS:Reactome.
 GO:0006936; P:muscle contraction; TAS:ProtInc.
 GO:0086014; P:regulation of atrial cardiac muscle cell action potential; TAS:BHF-UCL.
 GO:0007268; P:synaptic transmission; TAS:Reactome.
 GO:0006810; P:transport; NAS:ProtInc.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0007601; P:visual perception; IEA:Compara. 

Interpro

 IPR000500; Connexin.
 IPR002265; Connexin45.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 

Pfam

 PF00029; Connexin
 PF10582; Connexin_CCC 

SMART

 SM00037; CNX
 SM01089; Connexin_CCC 

PROSITE

 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 

PRINTS

 PR00206; CONNEXIN.
 PR01136; CONNEXINA6.