UniProt Accession

 DPP2_HUMAN; Q9UHL4; A8K7U7; Q5VSF1; Q969X4 

Genbank Protein ID

 AF154502; AK292112; AL929554; BC011907; BC016961 

Genbank Nucleotide ID

 AAF12747.1; BAF84801.1; CAH72872.1; AAH11907.1; AAH16961.1 

Protein Name

 Dipeptidyl peptidase 2 

Protein Synonyms/Alias

 Dipeptidyl aminopeptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; DPP II; Quiescent cell proline dipeptidase 

Gene Name

 DPP7 

Gene Synonyms/Alias

 DPP2; QPP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
112	AEHRYYGKSLPFGAQ	ubiquitination	[1, 2, 3, 4]
215	DFEGQSPKCTQGVRE	ubiquitination	[2, 3, 5, 6]
228	REAFRQIKDLFLQGA	ubiquitination	[1, 2, 3, 4]
463	ASVVEARKLEATIIG	ubiquitination	[3]
474	TIIGEWVKAARREQQ	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Plays an important role in the degradation of some oligopeptides. 

Sequence Annotation

 ACT_SITE 162 162 Charge relay system (Potential).
 ACT_SITE 418 418 Charge relay system (Potential).
 ACT_SITE 443 443 Charge relay system (Potential).
 CARBOHYD 50 50 N-linked (GlcNAc...).
 CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
 CARBOHYD 315 315 N-linked (GlcNAc...).
 CARBOHYD 356 356 N-linked (GlcNAc...) (Potential).
 CARBOHYD 363 363 N-linked (GlcNAc...) (Potential).
 CARBOHYD 428 428 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Aminopeptidase; Cleavage on pair of basic residues; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Glycoprotein; Hydrolase; Lysosome; Polymorphism; Protease; Reference proteome; Secreted; Serine protease; Signal; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 492 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0008239; F:dipeptidyl-peptidase activity; IEA:Compara.
 GO:0008236; F:serine-type peptidase activity; TAS:ProtInc.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR008758; Peptidase_S28. 

Pfam

 PF05577; Peptidase_S28 

SMART

  

PROSITE

  

PRINTS