CPLM-004170

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-004170

UniProt Accession

1A11_HUMAN; P13746; O19605; O19606; Q29747; Q29835; Q5S3G1; Q9BCN0; Q9MYI5; Q9TQE9; Q9TQP6; Q9TQP7

Genbank Protein ID

X13111; X13112; D16841; D16842; AJ306733; X91399; Y17224; Y17224; AH007763; AF165065; DQ336694; AY786586; AY786587; U50574; AH003070; AH005647; AH005646

Genbank Nucleotide ID

CAA31503.1; CAA31504.1; BAA04117.1; BAA04118.1; CAC37336.1; CAA62745.1; CAB38056.1; CAB38057.1; AAD33991.1; AAF25781.1; ABC59611.1; AAV53344.1; AAV53345.1; AAB60406.1; AAA65449.1; AAB87052.1; AAB87051.1

Protein Name

HLA class I histocompatibility antigen, A-11 alpha chain

Protein Synonyms/Alias

MHC class I antigen A*11

Gene Name

HLA-A

Gene Synonyms/Alias

HLAA

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
92	DQETRNVKAQSQTDR	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Involved in the presentation of foreign antigens to the immune system.

Sequence Annotation

DOMAIN 209 295 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
MOD_RES 356 356 Phosphoserine.
CARBOHYD 110 110 N-linked (GlcNAc...) (By similarity).
DISULFID 125 188
DISULFID 227 283

Keyword

3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Immunity; Membrane; MHC I; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

365 AA

Protein Sequence

MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF 60
DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ 120
IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHAAEQQ 180
RAYLEGRCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 240
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 300
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL 360
TACKV 365

Gene Ontology

GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
GO:0006955; P:immune response; NAS:UniProtKB.
GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW.

Interpro

IPR007110; Ig-like_dom.
IPR013783; Ig-like_fold.
IPR003006; Ig/MHC_CS.
IPR003597; Ig_C1-set.
IPR011161; MHC_I-like_Ag-recog.
IPR011162; MHC_I/II-like_Ag-recog.
IPR001039; MHC_I_a_a1/a2.
IPR010579; MHC_I_a_C.

Pfam

PF07654; C1-set
PF00129; MHC_I
PF06623; MHC_I_C

SMART

SM00407; IGc1

PROSITE

PS50835; IG_LIKE
PS00290; IG_MHC

PRINTS

PR01638; MHCCLASSI.