UniProt Accession

 NHP2_MOUSE; Q9CRB2 

Genbank Protein ID

 AK007340; AK008766; AK019134; BC024944 

Genbank Nucleotide ID

 BAB24973.1; BAB25882.1; BAB31561.1; AAH24944.1 

Protein Name

 H/ACA ribonucleoprotein complex subunit 2 

Protein Synonyms/Alias

 Nucleolar protein family A member 2; snoRNP protein NHP2 

Gene Name

 Nhp2 

Gene Synonyms/Alias

 Nola2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
25	CSEERTYKELLVNLN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). 

Sequence Annotation

 MOD_RES 19 19 Phosphoserine (By similarity).
 CROSSLNK 5 5 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005732; C:small nucleolar ribonucleoprotein complex; ISS:UniProtKB.
 GO:0030515; F:snoRNA binding; ISS:UniProtKB.
 GO:0031118; P:rRNA pseudouridine synthesis; ISS:UniProtKB. 

Interpro

 IPR002415; H/ACA_rnp_Nhp2_euk.
 IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
 IPR018492; Ribosomal_L7Ae/L8/Nhp2. 

Pfam

 PF01248; Ribosomal_L7Ae 

SMART

  

PROSITE

 PS01082; RIBOSOMAL_L7AE 

PRINTS

 PR00881; L7ARS6FAMILY.
 PR00883; NUCLEARHMG.