UniProt Accession

 A8MVQ8_HUMAN; A8MVQ8 

Genbank Protein ID

 AL391994; AK293278; CH471098 

Genbank Nucleotide ID

 BAH11480.1; EAW70018.1 

Protein Name

 Geranylgeranyl diphosphate synthase 1, isoform CRA_b 

Protein Synonyms/Alias

 Geranylgeranyl pyrophosphate synthase; cDNA FLJ59463, highly similar to Geranylgeranyl pyrophosphate synthetase 

Gene Name

 GGPS1 

Gene Synonyms/Alias

 hCG_19067 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
17	DDIEDNSKLRRGFPV	ubiquitination	[1]
59	LDHPDAVKLFTRQLL	ubiquitination	[2]
142	DYANLHSKEYSENKS	ubiquitination	[3]
219	ELEAKAYKQIDARGG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Isoprene biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0004337; F:geranyltranstransferase activity; IEA:Compara.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR000092; Polyprenyl_synt.
 IPR017446; Polyprenyl_synth-rel.
 IPR008949; Terpenoid_synth. 

Pfam

 PF00348; polyprenyl_synt 

SMART

  

PROSITE

 PS00723; POLYPRENYL_SYNTHASE_1
 PS00444; POLYPRENYL_SYNTHASE_2 

PRINTS