CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000378
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FYN-binding protein 
Protein Synonyms/Alias
 Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein 
Gene Name
 FYB 
Gene Synonyms/Alias
 SLAP130 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
3*****MAKYNTGGNPacetylation[1]
149VNQDHDLKPLGPKSGacetylation[1]
179KLTGVKGKFMSASQDacetylation[2]
223MKNVSSSKGSPAPLGubiquitination[2]
265PFPGVVLKPAASRGGacetylation[1]
425SLPPRNIKPPFDLKSacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. 
Sequence Annotation
 DOMAIN 514 570 SH3.
 REGION 348 448 Interaction with SKAP1.
 MOTIF 462 465 SH2-binding (Potential).
 MOTIF 469 505 Nuclear localization signal (Potential).
 MOTIF 595 598 SH2-binding; to LCP2.
 MOTIF 625 628 SH2-binding; to FYN.
 MOTIF 674 700 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 3 3 N6-acetyllysine.
 MOD_RES 28 28 Phosphoserine (By similarity).
 MOD_RES 46 46 Phosphoserine.
 MOD_RES 457 457 Phosphoserine.
 MOD_RES 571 571 Phosphotyrosine.
 MOD_RES 573 573 Phosphoserine.
 MOD_RES 651 651 Phosphotyrosine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 783 AA 
Protein Sequence
MAKYNTGGNP TEDVSVNSRP FRVTGPNSSS GIQARKNLFN NQGNASPPAG PSNVPKFGSP 60
KPPVAVKPSS EEKPDKEPKP PFLKPTGAGQ RFGTPASLTT RDPEAKVGFL KPVGPKPINL 120
PKEDSKPTFP WPPGNKPSLH SVNQDHDLKP LGPKSGPTPP TSENEQKQAF PKLTGVKGKF 180
MSASQDLEPK PLFPKPAFGQ KPPLSTENSH EDESPMKNVS SSKGSPAPLG VRSKSGPLKP 240
AREDSENKDH AGEISSLPFP GVVLKPAASR GGPGLSKNGE EKKEDRKIDA AKNTFQSKIN 300
QEELASGTPP ARFPKAPSKL TVGGPWGQSQ EKEKGDKNSA TPKQKPLPPL FTLGPPPPKP 360
NRPPNVDLTK FHKTSSGNST SKGQTSYSTT SLPPPPPSHP ASQPPLPASH PSQPPVPSLP 420
PRNIKPPFDL KSPVNEDNQD GVTHSDGAGN LDEEQDSEGE TYEDIEASKE REKKREKEEK 480
KRLELEKKEQ KEKEKKEQEI KKKFKLTGPI QVIHLAKACC DVKGGKNELS FKQGEQIEII 540
RITDNPEGKW LGRTARGSYG YIKTTAVEID YDSLKLKKDS LGAPSRPIED DQEVYDDVAE 600
QDDISSHSQS GSGGIFPPPP DDDIYDGIEE EDADDGFPAP PKQLDMGDEV YDDVDTSDFP 660
VSSAEMSQGT NVGKAKTEEK DLKKLKKQEK EEKDFRKKFK YDGEIRVLYS TKVTTSITSK 720
KWGTRDLQVK PGESLEVIQT TDDTKVLCRN EEGKYGYVLR SYLADNDGEI YDDIADGCIY 780
DND 783 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; TAS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0005102; F:receptor binding; TAS:UniProtKB.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0007243; P:intracellular protein kinase cascade; TAS:ProtInc.
 GO:0006607; P:NLS-bearing substrate import into nucleus; TAS:ProtInc.
 GO:0006468; P:protein phosphorylation; TAS:ProtInc.
 GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF07653; SH3_2 
SMART
 SM00326; SH3 
PROSITE
 PS50002; SH3 
PRINTS