UniProt Accession

 NMNA3_MOUSE; Q99JR6; Q58E37 

Genbank Protein ID

 BC005737; BC092086 

Genbank Nucleotide ID

 AAH05737.1; AAH92086.1 

Protein Name

 Nicotinamide mononucleotide adenylyltransferase 3 

Protein Synonyms/Alias

 NMN adenylyltransferase 3; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1 

Gene Name

 Nmnat3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
158	HIQEIVEKFGLVCVS	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury. 

Sequence Annotation

 NP_BIND 13 22 ATP (Potential).
 NP_BIND 200 205 ATP (Potential).
 BINDING 14 14 Substrate (By similarity).
 BINDING 53 53 Substrate (By similarity).
 BINDING 136 136 Substrate (By similarity).  

Keyword

 ATP-binding; Complete proteome; Mitochondrion; NAD; Nucleotide-binding; Nucleotidyltransferase; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000309; F:nicotinamide-nucleotide adenylyltransferase activity; IDA:MGI.
 GO:0004515; F:nicotinate-nucleotide adenylyltransferase activity; IEA:EC.
 GO:0009435; P:NAD biosynthetic process; IDA:MGI.
 GO:0009611; P:response to wounding; IDA:MGI. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR005248; NAMN_adtrnsfrase.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01467; CTP_transf_2 

SMART

  

PROSITE

  

PRINTS