UniProt Accession

 CALM_BOVIN; P62157; P02593; P70667; P99014; Q08D84; Q2KJE6; Q61379; Q61380 

Genbank Protein ID

 AB099053; BC105380; BC120080; BC123890 

Genbank Nucleotide ID

 BAC56543.1; AAI05381.1; AAI20081.1; AAI23891.1 

Protein Name

 Calmodulin 

Protein Synonyms/Alias

 CaM 

Gene Name

 CALM 

Gene Synonyms/Alias

 CAM 

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
14	EEQIAEFKEAFSLFD	ubiquitination	[1]
22	EAFSLFDKDGDGTIT	ubiquitination	[1]
95	EAFRVFDKDGNGYIS	ubiquitination	[1]

Reference

 [1] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080] 

Functional Description

 Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). 

Sequence Annotation

 DOMAIN 8 43 EF-hand 1.
 DOMAIN 44 79 EF-hand 2.
 DOMAIN 81 116 EF-hand 3.
 DOMAIN 117 149 EF-hand 4.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 22 22 N6-acetyllysine; alternate (By
 MOD_RES 45 45 Phosphothreonine; by CaMK4 (By
 MOD_RES 95 95 N6-acetyllysine (By similarity).
 MOD_RES 100 100 Phosphotyrosine (By similarity).
 MOD_RES 102 102 Phosphoserine (By similarity).
 MOD_RES 116 116 N6,N6,N6-trimethyllysine.
 MOD_RES 139 139 Phosphotyrosine (By similarity).
 CROSSLNK 22 22 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Calcium; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Isopeptide bond; Metal-binding; Methylation; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005876; C:spindle microtubule; IEA:Compara.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IDA:BHF-UCL.
 GO:0060315; P:negative regulation of ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
 GO:0060316; P:positive regulation of ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
 GO:0032465; P:regulation of cytokinesis; IEA:Compara.
 GO:0010880; P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IDA:BHF-UCL.
 GO:0051592; P:response to calcium ion; IEA:Compara. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001125; Recoverin. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS

 PR00450; RECOVERIN.