UniProt Accession

 LTOR3_MOUSE; O88653 

Genbank Protein ID

 AF082526; BC016417; BC083155 

Genbank Nucleotide ID

 AAC34591.1; AAH16417.1; AAH83155.1 

Protein Name

 Ragulator complex protein LAMTOR3 

Protein Synonyms/Alias

 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MEK-binding partner 1; Mp1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1 

Gene Name

 Lamtor3 

Gene Synonyms/Alias

 Map2k1ip1; Mapbp; Mapksp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
62	LATDQGSKLGLSKNK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. 

Sequence Annotation

 REGION 57 70 Required for interaction with LAMTOR2.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Endosome; Membrane; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 124 AA 

Protein Sequence

Gene Ontology

 GO:0071986; C:Ragulator complex; ISS:UniProtKB.
 GO:0034613; P:cellular protein localization; ISS:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; ISS:UniProtKB. 

Interpro

 IPR015019; LAMTOR3. 

Pfam

 PF08923; MAPKK1_Int 

SMART

  

PROSITE

  

PRINTS