| Tag | Content |
|---|
| CPLM ID | CPLM-013152 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Paternally-expressed gene 3 protein |
Protein Synonyms/Alias | ASF-1 |
Gene Name | Peg3 |
Gene Synonyms/Alias | Kiaa0287; Pw1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 551 | RGNPFENKSRMCEET | ubiquitination | [1] | | 575 | RQKTYREKLFDFNNA | ubiquitination | [1] | | 597 | SDSSEHQKNRSRRNF | ubiquitination | [1] | | 647 | VNPNDKLKFPIMENG | ubiquitination | [1] | | 930 | SNNLSVQKIYAQETF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Plays a role in regulating maternal behavior and offspring growth. |
Sequence Annotation | REPEAT 942 946 1-1.
REPEAT 967 971 1-2.
REPEAT 987 991 2-1.
REPEAT 992 996 1-3.
REPEAT 997 1001 2-2.
REPEAT 1002 1006 1-4.
REPEAT 1007 1011 2-3.
REPEAT 1012 1016 1-5.
REPEAT 1017 1021 1-6.
REPEAT 1022 1026 1-7.
REPEAT 1027 1031 1-8.
REPEAT 1032 1036 1-9.
REPEAT 1047 1051 1-10.
ZN_FING 325 347 C2H2-type 1.
ZN_FING 378 400 C2H2-type 2.
ZN_FING 436 458 C2H2-type 3.
ZN_FING 520 542 C2H2-type 4.
ZN_FING 850 872 C2H2-type 5.
ZN_FING 1091 1113 C2H2-type 6.
ZN_FING 1147 1169 C2H2-type 7.
ZN_FING 1209 1231 C2H2-type 8.
ZN_FING 1266 1289 C2H2-type 9.
ZN_FING 1317 1339 C2H2-type 10; degenerate.
ZN_FING 1488 1510 C2H2-type 11.
ZN_FING 1547 1569 C2H2-type 12.
REGION 199 265 10 X 5 AA repeat of P-H-X-X-E.
REGION 199 265 3 X 5 AA repeat of P-H-D-D-K. |
Keyword | Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1571 AA |
Protein Sequence | MYHHEDDTNS DMNSDDDMSR SGRETPPPRP SHAFGSERDL ERRGRSRDVE PRDRWPYTRN 60
PRSRLPQRDL SLPVMSRPHF GLDRDDDRRS MDYESRSQDA ESYQNVVELK EDKKPQNPIQ 120
DNLENYRKLL SLGVQLAEDD RHSHMTQGHS SRSKRTAYPS TSRGLKPMPE AKKPSHRRGI 180
CEDESSHGVI MEKFIKDVAR NPKSGRAREL NERPPPRFPR PNDNWKDSSS SRRESVIQER 240
GYEGSAFRGG FRFNADLASR SRALERKRRY HFDSDERGSG HEHKSCVRKK PFECGAEMRQ 300
AMSMGNLNSP SFSESQSIDF GANPYVCDEC GRQFSVISEF VEHQIMHTRE NLYEYGESFI 360
HSVAVNEVQK GQGGGKRFEC KECGETFSRS AALAEHRQIH AREYLAECRD QEDEETIMPS 420
PTFSELQKMY GKDKFYECKV CKETFLHSSA LIEHQKIHGR GNSDDRDNER ERERDRLRAR 480
AREQRERERE RERERELGEP FLTCPNFNEF RKMYRKDKIY ECKVCGESFL HLSSLREHQK 540
IHTRGNPFEN KSRMCEETFV PSQSLRRRQK TYREKLFDFN NARDALMGNS DSSEHQKNRS 600
RRNFFEGRGF EKPFVESQKS HTITRPPENK DDDKPFTISV NPNDKLKFPI MENGSQGKSY 660
ERSVIHSLGS AEAQKSHGGL GFSKPRPVAE SSTQSSSSIY YPRAHSGGNT YEGKEYKDSI 720
IHSLPAPRPL KRHRANDHIQ CDEGGESSIY IPDIINKGRK IPAREDAYEG SSSSNYHTPN 780
VSRAEPPSLS GESHDSKQDV TFSVPSSSVR EHQKARAKKK YIEPRNNETS VIHSLPFGEL 840
LAGHRRAKFF ECQECGEAFA RRSELIEHQK IHDRERPSGS RHYERSVIRS LAPSDPQTSY 900
AQERFIQEQV RKFRAFGQRS TTSNNLSVQK IYAQETFNAE EPHDKETHGQ KIHDKEPYGK 960
EPSGKEPHGD EPQDKEPLDQ EMRSEEPHDD KPHGQEPHDD KPHGQEPHDD KPHGQEPHGD 1020
EPHGQEPHGD EPHDKEPIDQ EMRSEEPHSE ESHGDEPHGE ESHGQEKVED ATIQASVSEE 1080
HQKDDAGDAI YECQDCGLGF TDLNDLTSHQ DTHSRKALVD SREYAHSEVH AHSVSEFEKK 1140
CSGEKLYECP KCGESFIHSS LLFEHQRVHE QDQLYSVKAC DDAFIALLPV RPRRNCTVER 1200
NPAVSGSAIR CRQCGQGFIH SSALNEHMRQ HRDNEIMEQS ELSDEIFIQG LALTEYQGSE 1260
TEEKLFECTI CGECFFTAKQ LGDHHTKVHK DEPYEYGPSY THASFLTEPL RKHIPLYECK 1320
DCGQSFLDDT VIAERMVFHP EREGGSEIVA ATAQEVEANV LIPQEVLRIQ GSNAEAAEPE 1380
VEAAEPEVEA AEPEVEAAEP NGEAEGPDGE AAEPDGEAEQ PNGEAEQPNG DADEPDGAGI 1440
EDPEERADEP EEDVEEPEGD ADEPDGADIE DPEEEGEDQE IEVEEPYYNC HECAETFASS 1500
SAFGEHLKSH ASVIIFEPAN APGECSGYIE RASTSAGGAE QADDKYFKCD VCGQLFNDRL 1560
SLARHQNSHT G 1571 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |