CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023419
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60 kDa heat shock protein homolog 1, mitochondrial 
Protein Synonyms/Alias
 60 kDa chaperonin; CPN60; Heat shock protein 60; HSP-60; Hsp60 
Gene Name
 Hsp60B 
Gene Synonyms/Alias
 CG2830 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
148AVDVVKDKLKEMSKAacetylation[1]
150DVVKDKLKEMSKAVEacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 648 AA 
Protein Sequence
MFRSCVPKAI TSSRCFARMY SKDVRFGSGV RAMMIRGVDI LADAVAVTMG PKGRSVIVER 60
PWTSPKITKD GFTVARSIAL KDQHMNLGAK LVQDVADNTN ESAGDGTTTA TVLARAIAKE 120
GFNQITMGAN PVEIRRGVML AVDVVKDKLK EMSKAVETRE EIQQVATLSA NGDTEIGRLI 180
GEATDKVGPR GTITVKDGKR LKDELNIIQG LRFDNGYVSP FFVNSSKGSK VEFANALVMI 240
SLKKITGLSQ IVKGLEQSLR QRRPLIIIAE DISGEALNAL VLNKLRLGLQ VCAVKSPSYG 300
HHRKELIGDI SAATGATIFG DDINYSKMEE AKLEDLGQVG EAVISKDSTM LLQGKPKTGL 360
LEMRIQQIQD ELAEKQIKPE QRDRLRQRLS ALTKGVAVLH IGGGSEVEVN EKKDRVVDAL 420
NATRAAIEEG IVPGGGTAFL RCIPYLQELK TESADLQKGV DIVCNALRMP CQTIAQNAGV 480
DGPMVVAKVL NGSEDYGYDA MGDEYCRLVE KGIIDPTKVL RTAITDAAGV ASLLSTTEVV 540
ITDSRNDDLL SKLSGAGGGM DDGLDMNMGG LEELAALSGL GGMGGMGGMG GMGGMGGMGG 600
GFGGMGAGGG MSASASNDGP TAEEMNEMVK AIPGMEQVEV RDIDSGMM 648 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042026; P:protein refolding; ISS:FlyBase.
 GO:0007286; P:spermatid development; IMP:FlyBase. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.