UniProt Accession

 MBP_CAVPO; P25188 

Genbank Protein ID

 AF074337 

Genbank Nucleotide ID

 AAC26130.1 

Protein Name

 Myelin basic protein 

Protein Synonyms/Alias

 MBP 

Gene Name

 MBP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Cavia porcellus (Guinea pig) 

NCBI Taxa ID

 10141 

Lysine Modification

Position	Peptide	Type	References
75	HYGSLPQKSQRSQDE	acetylation	[1]

Reference

 [1] Proton NMR study of peptides from myelin basic protein: evidence for Lys74-His77 interaction revealed from histidine line broadening.
 Koshy KM, Hashim GA, Boggs JM.
 Biochim Biophys Acta. 1996 Mar 7;1293(1):23-30. [PMID: 8652624] 

Functional Description

 Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). 

Sequence Annotation

 REGION 45 87 Induces experimental autoimmune
 REGION 114 122 Induces experimental autoimmune
 MOD_RES 1 1 N-acetylalanine.
 MOD_RES 7 7 Phosphoserine (By similarity).
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 25 25 Citrulline (By similarity).
 MOD_RES 31 31 Citrulline (By similarity).
 MOD_RES 35 35 Phosphothreonine (By similarity).
 MOD_RES 40 40 Phosphoserine (By similarity).
 MOD_RES 56 56 Phosphoserine (By similarity).
 MOD_RES 69 69 Phosphotyrosine (By similarity).
 MOD_RES 71 71 Phosphoserine (By similarity).
 MOD_RES 94 94 Phosphothreonine (By similarity).
 MOD_RES 97 97 Phosphothreonine (By similarity).
 MOD_RES 102 102 Deamidated glutamine (By similarity).
 MOD_RES 106 106 Omega-N-methylarginine; alternate (By
 MOD_RES 106 106 Symmetric dimethylarginine; alternate (By
 MOD_RES 114 114 Phosphoserine (By similarity).
 MOD_RES 121 121 N6-acetyllysine (By similarity).
 MOD_RES 129 129 Citrulline (By similarity).
 MOD_RES 144 144 Deamidated glutamine (By similarity).
 MOD_RES 156 156 Citrulline (By similarity).
 MOD_RES 158 158 Phosphoserine (By similarity).
 MOD_RES 162 162 Phosphoserine; by UHMK1 (By similarity).
 MOD_RES 167 167 Citrulline (By similarity).  

Keyword

 Acetylation; Autoimmune encephalomyelitis; Cell membrane; Citrullination; Complete proteome; Direct protein sequencing; Membrane; Methylation; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 167 AA 

Protein Sequence

Gene Ontology

 GO:0043209; C:myelin sheath; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0019911; F:structural constituent of myelin sheath; IEA:InterPro. 

Interpro

 IPR000548; Myelin_BP. 

Pfam

 PF01669; Myelin_MBP 

SMART

  

PROSITE

 PS00569; MYELIN_MBP 

PRINTS

 PR00212; MYELINMBP.