CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015314
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box only protein 38 
Protein Synonyms/Alias
 Modulator of KLF7 activity homolog; MoKA 
Gene Name
 FBXO38 
Gene Synonyms/Alias
 SP329 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
250AGPTNSLKYVPLVTGubiquitination[1, 2, 3, 4]
333RIQPSLTKDGVFSALubiquitination[2, 4]
628RYSEREEKTGESVQSubiquitination[5]
980FDYAQCKKLNMDQVLubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
 Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination (By similarity). 
Sequence Annotation
 DOMAIN 30 75 F-box.
 REGION 59 119 Interaction with KLF7 (By similarity).
 MOD_RES 736 736 Phosphoserine.
 MOD_RES 826 826 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1188 AA 
Protein Sequence
MGPRKKSVKT CIMNNEIPEE MTADETKDYM NQLSHEVLCH IFRYLPLQDI MCMECLSRKL 60
KEAVTLYLRV VRVVDLCAGR WWEYMPSGFT DASFLTLLKK MPDVEQLYGL HPRYLERRRV 120
RGHEAFSIPG VLEALQACPN LVGVETSHLE LVESIWTYMP HVHILGKFRN RNGAFPIPPE 180
NKLKIPIGAK IQTLHLVGVN VPEIPCIPML RHLYMKWVRL TKPQPFKDFL CISLRTFVMR 240
NCAGPTNSLK YVPLVTGLAS ARNLEHLEMV RVPFLGGLIQ HVVEDSWRSG GFRNLHTIVL 300
GACKNALEVD LGYLIITAAR RLHEVRIQPS LTKDGVFSAL KMAELEFPQF ETLHLGYVDE 360
FLLQSRMANA DLVKYGLADV VENPGIITDI GMKAVNEVFS CIKYLAIYNC PHLHNPYNWI 420
SDHSRWTRLV DINLVRCHAL KLDSFGQFIE LLPSLEFISL DQMFREPPKG CARVGLSAGT 480
GIGVSSALVS NQNSNNDDNN AQNNNANIHD NNHHHPDDSD EENDFRQDLQ PGEQQFAADA 540
LNEMEDIVQE DGEVVAESGN NTPAHSQAII PVDVDEEQAG PSGLQRVVKP TSITVHDSES 600
DDEEDSLELQ EVWIPKNGTR RYSEREEKTG ESVQSRELSV SGKGKTPLRK RYNSHQMGQS 660
KQFPLEESSC EKGCQVTSEQ IKADMKAARD IPEKKKNKDV YPSCSSTTAS TVGNSSSHNT 720
ASQSPDFVRT VNSGGSSEPS PTEVDVSRQC ACSPGGSEDS EAMEEGDAES SVCPRCCCHR 780
PQESQRRTSR CSDEERPSTS RACVVNGPDG TRSAFSFRTL PQGGSSGPAH DERTNGSGSG 840
ATGEDRRGSS QPESCDVQSN EDYPRRPLTR ARSRLSHVLL VSESEVAKTK PRHAMKRKRT 900
ADKSTSTSDP VIEDDHVQVL VLKSKNLVGV TMTNCGITDL VLKDCPKMMF IHATRCRVLK 960
HLKVENAPIV NRFDYAQCKK LNMDQVLDQI LRMPPERNRI IYLRPMQQVD TLTLEQKLFS 1020
GPYPYHICII HEFSNPPNVR NKVRIRSWMD TIANINQELI KYEFFPEATR SEEDLKKYPK 1080
YPWGREIYTL EGVVDGAPYS MISDFPWLRS LRAAEPNSFA RYDFEDDEES TIYAPRRKGQ 1140
LSADICMETI GEEISEMRQM KKGVFQRVVA IFIHYCDVNG EPVEDDYI 1188 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR001810; F-box_dom_cyclin-like. 
Pfam
  
SMART
  
PROSITE
 PS50181; FBOX 
PRINTS