CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021740
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family B member 10, mitochondrial 
Protein Synonyms/Alias
 ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein 
Gene Name
 Abcb10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
230QEVAFFDKTRTGELIacetylation[1, 2]
673VAVLDHGKICEHGTHacetylation[2]
686THEELLLKPNGLYRKacetylation[2]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 May mediate critical mitochondrial transport functions related to heme biosynthesis. 
Sequence Annotation
 DOMAIN 136 422 ABC transmembrane type-1.
 DOMAIN 457 696 ABC transporter.
 NP_BIND 492 499 ATP (Potential).
 MOD_RES 230 230 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; ATP-binding; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 715 AA 
Protein Sequence
MRAPSARALL LIPRRGPAVR AWAPAVSSRI WLASEWTPLV RAWTSLIHKP GSGLRFPAPL 60
SGLPGGVGQW ATSSGARRCW VLAGPRAAHP LFARLQGAAA TGVRDLGNDS QRRPAATGRS 120
EVWKLLGLVR PERGRLSAAV GFLAVSSVIT MSAPFFLGRI IDVIYTNPSE GYGDSLTRLC 180
AVLTCVFLCG AAANGIRVYL MQSSGQSIVN RLRTSLFSSI LRQEVAFFDK TRTGELINRL 240
SSDTALLGRS VTENLSDGLR AGAQASVGVG MMFFVSPSLA TFVLSVVPPI SVLAVIYGRY 300
LRKLSKATQD SLAEATQLAE ERIGNIRTIR AFGKEMTEVE KYTGRVDQLL QLAQKEALAR 360
AGFFGAAGLS GNLIVLSVLY KGGLLMGSAH MTVGELSSFL MYAFWVGLSI GGLSSFYSEL 420
MKGLGAGGRL WELLERQPRL PFNEGMVLDE KTFQGALEFR NVHFTYPARP EVSVFQDFSL 480
SIPSGSVTAL VGPSGSGKST VVSLLLRLYD PNSGTVSLDG HDIRQLNPVW LRSKIGTVSQ 540
EPVLFSCSVA ENIAYGADNL SSVTAQQVER AAEVANAAEF IRSFPQGFDT VVGEKGILLS 600
GGQKQRIAIA RALLKNPKIL LLDEATSALD AENEHLVQEA LDRLMEGRTV LIIAHRLSTI 660
KNANFVAVLD HGKICEHGTH EELLLKPNGL YRKLMNKQSF LSYNGAEQFL EPARA 715 
Gene Ontology
 GO:0016021; C:integral to membrane; IBA:RefGenome.
 GO:0032592; C:integral to mitochondrial membrane; IEA:Compara.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015421; F:oligopeptide-transporting ATPase activity; IBA:RefGenome. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS