CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021380
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTP-binding protein 5 
Protein Synonyms/Alias
 Protein obg homolog 1; ObgH1 
Gene Name
 GTPBP5 
Gene Synonyms/Alias
 OBGH1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
123LRVDQQVKSLSSVLSubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Involved in the ribosome maturation process. Plays a role of GTPase in vitro. When missing, mitochondria elongation and abnormal nuclear morphology are observed. 
Sequence Annotation
 DOMAIN 236 346 G.
 NP_BIND 231 238 GTP (Potential).
 NP_BIND 278 282 GTP (Potential).
 NP_BIND 345 348 GTP (Potential).
 REGION 15 406 Localized in the mitochondria.
 REGION 30 406 Not localized in the mitochondria.  
Keyword
 Complete proteome; GTP-binding; Mitochondrion; Nucleotide-binding; Polymorphism; Reference proteome; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MAPARCFSAR LRTVFQGVGH WALSTWAGLK PSRLLPQRAS PRLLSVGRAD LAKHQELPGK 60
KLLSEKKLKR YFVDYRRVLV CGGNGGAGAS CFHSEPRKEF GGPDGGDGGN GGHVILRVDQ 120
QVKSLSSVLS RYQGFSGEDG GSKNCFGRSG AVLYIRVPVG TLVKEGGRVV ADLSCVGDEY 180
IAALGGAGGK GNRFFLANNN RAPVTCTPGQ PGQQRVLHLE LKTVAHAGMV GFPNAGKSSL 240
LRAISNARPA VASYPFTTLK PHVGIVHYEG HLQIAVADIP GIIRGAHQNR GLGSAFLRHI 300
ERCRFLLFVV DLSQPEPWTQ VDDLKYELEM YEKGLSARPH AIVANKIDLP EAQANLSQLR 360
DHLGQEVIVL SALTGENLEQ LLLHLKVLYD AYAEAELGQG RQPLRW 406 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR014100; GTP-bd_Obg/CgtA.
 IPR006169; GTP1_OBG_dom.
 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom. 
Pfam
 PF01018; GTP1_OBG
 PF01926; MMR_HSR1 
SMART
  
PROSITE
  
PRINTS
 PR00326; GTP1OBG.